Tuftsin

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Tuftsin; 纯度: 98.86%

Tuftsin 是一种四肽。Tuftsin是巨噬细胞/小胶质细胞激活剂。

Tuftsinamp;;

Tuftsin Chemical Structure

CAS No. : 9063-57-4

规格 价格 是否有货 数量
5 mg ￥550 In-stock
10 mg ￥770 In-stock
25 mg ￥1450 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Tuftsin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Peptidomimetic Library
  • Peptide Library

生物活性

Tuftsin is a tetrapeptide. Tuftsin is a macrophage/microglial activator.

IC50 Target

Human Endogenous Metabolite

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体外研究
(In Vitro)

Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin’s capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes[1]. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

500.59

Formula

C21H40N8O6
CAS 号

9063-57-4
Sequence

Thr-Lys-Pro-Arg
Sequence Shortening

TKPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (199.76 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9976 mL 9.9882 mL 19.9764 mL
5 mM 0.3995 mL 1.9976 mL 3.9953 mL
10 mM 0.1998 mL 0.9988 mL 1.9976 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fridkin M, et al. Tuftsin: its chemistry, biology, and clinical potential. Crit Rev Biochem Mol Biol. 1989;24(1):1-40.

    [2]. Wu M, et al. Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimentalautoimmune encephalomyelitis. PLoS One. 2012;7(4):e34933.