Proctolin(Synonyms: 直肠肽)

发表于由

Proctolin;(Synonyms: 直肠肽) 纯度: ge;98.0%

Proctolin 是一种内源性五肽，用作兴奋性神经调节剂。

Proctolinamp;;(Synonyms: 直肠肽)

Proctolin Chemical Structure

CAS No. : 57966-42-4

规格 价格 是否有货 数量
1 mg ￥900 In-stock
5 mg ￥2200 In-stock
10 mg ￥3500 In-stock
25 mg ￥4900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Proctolin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Peptidomimetic Library
  • Peptide Library

生物活性

Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.

体外研究
(In Vitro)

Proctolin can increase the frequency of action potentials, increase the amplitude of muscle contraction, and initiate activity in quiescent systems[1]. In the arthropods, Proctolin acts as a neuromodulator and possibly as a neurohormone. It does not appear to function as a conventional neurotransmitter[2]. Proctolin is a pentapeptide with the mature peptide of RYLPT, and it is the first insect neuropeptide to be sequenced and chemically characterized. The first identification of a Proctolin precursor gene is CG7105 in D. melanogaster. Although a previous study showed that Proctolin is absent in B. mori, this pentapeptide is recently identified in a proteomic analysis of B. mori wings. However, the Bombyx Proctolin gene does not produce a mature peptide because cleavage sites are not present at the N-terminal and C-terminal of the RYLPT sequence, and a similar gene is observed in C. suppressalis. Therefore, a true Proctolin has been considered to be not observed in B. mori and C. suppressalis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

648.75

Formula

C30H48N8O8
CAS 号

57966-42-4
Sequence

Arg-Tyr-Leu-Pro-Thr
Sequence Shortening

RYLPT
中文名称

直肠肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (154.14 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5414 mL 7.7071 mL 15.4143 mL
5 mM 0.3083 mL 1.5414 mL 3.0829 mL
10 mM 0.1541 mL 0.7707 mL 1.5414 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. McGrath LL, et al. De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. BMC Genomics. 2016 Jan 16;17:63.

    [2]. Orchard I, et al. Proctolin: a review with emphasis on insects. J Neurobiol. 1989 Jul;20(5):470-96.

    [3]. Xu G, et al. Identification and expression profiles of neuropeptides and their G protein-coupled receptors in the rice stem borer Chilo suppressalis. Sci Rep. 2016 Jun 29;6:28976.