RO27-3225 TFA; 纯度: 99.57%
RO27-3225 TFA 是一种有效的选择性黑皮质素 4 受体 (MC4R) 激动剂,对于 MC4R 和 MC1R 的 EC50 分别为 1 nM 和 8 nM。RO27-3225 TFA 对 MC4R 的选择性是 MC3R 的 30 倍左右。RO27-3225 TFA 具有神经保护和抗炎作用。
RO27-3225 TFA Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥4750 | In-stock | |
5 mg | ¥3000 | In-stock | |
10 mg | ¥4800 | In-stock | |
50 mg | ¥13500 | In-stock | |
100 mg | ; | 询价 | ; |
200 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
RO27-3225 TFA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- GPCR/G Protein Compound Library
- Immunology/Inflammation Compound Library
- Neuronal Signaling Compound Library
- Neuroprotective Compound Library
- Anti-Obesity Compound Library
- Peptide Library
生物活性 |
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects[1][2][3]. |
IC50 Target |
EC50: 1 nM (Melanocortin 4 receptor (MC4R)), 8 nM (MC1R), 675 nM (MC3R) and 5779 nM (MC5R)[1] |
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体内研究 (In Vivo) |
RO27-3225 (0.012-0.048 mg/kg; intravenous injection; Wistar rats) treatment reverses haemorrhagic shock, reduces multiple organ damage and improves survival. RO27-3225 could have a protective role against multiple organ failure following circulatory shock[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
898.93 |
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Formula |
C41H53F3N12O8 |
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Sequence |
Oxobutyl-His-Phe-Arg-Trp-{Sar}-NH2 |
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Sequence Shortening |
Oxobutyl-HFRW-{Sar}-NH2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture and light
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:;
H2O : 100 mg/mL (111.24 mM; Need ultrasonic) DMSO : 100 mg/mL (111.24 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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