Neuropeptide W-23(human);(Synonyms: NPW-23) 纯度: 95.02%
Neuropeptide W-23(human) 是 Neuropeptide W 的主要活性形式,为 NPBW1 和 NPBW2 的内源性配体。
Neuropeptide W-23(human) Chemical Structure
CAS No. : 383415-79-0
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥2200 | In-stock | |
5 mg | ¥9900 | In-stock | |
10 mg | ; | 询价 | ; |
50 mg | ; | 询价 | ; |
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生物活性 |
Neuropeptide W-23(human), the active form of Neuropeptide W, is an endogenous ligand for NPBW1 and NPBW2. |
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体外研究 (In Vitro) |
NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats[1]. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
2583.02 |
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Formula |
C120H184N34O28S |
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CAS 号 |
383415-79-0 |
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Sequence Shortening |
WYKHVASPRYHTVGRAAGLMGL |
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中文名称 |
神经肽 W-23 (人) |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
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参考文献 |
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Animal Administration [2] |
Cardiovascular experiments are conducted the day after carotid implantation. On the day of the experiment, animals are habituated to a quiet room for at least 2 h. The carotid cannula is flushed with heparinized saline (200 U/mL in 0.9% NaCl) and connected to a pressure transducer. Baseline MAP is recorded for at least 30 min at 1-min intervals. For all experiments, preinjection baseline is calculated as the average MAP for 10 min before intracerebroventricular injections of saline or NPW-23. To test the cardiovascular effects of centrally administered NPW-23, rats are treated intracerebroventricularly with vehicle or vehicle containing 0.3, 1.0, or 3.0 nmol NPW-23. MAP is recorded for at least 45 min at 1-min intervals. To determine the potential role of sympathetic activation in mediating NPW-induced MAP increase, rats are pretreated intra-arterially with the α-adrenergic antagonist phentolamine-HCl (10 mg/kg body wt in 0.9% NaCl) or saline 15 min before central injection of saline or saline containing 1.0 nmol NPW-23. In a final experiment, the OX1R antagonist, SB-408124, or vehicle is injected intracerebroventricularly 15 s prior to 1.0 nmol NPW-23, and MAP is monitored for 45 min at 1-min intervals. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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