[Met5]-Enkephalin, amide TFA(Synonyms: 5-Methionine-enkephalin amide TFA)

发表于由

[Met5]-Enkephalin, amide TFA;(Synonyms: 5-Methionine-enkephalin amide TFA) 纯度: 99.71%

[Met5]-Enkephalin, amide TFA 是一种 δ 和 ζ 阿片受体 (opioid receptor) 激动剂。

[Met5]-Enkephalin, amide TFAamp;;(Synonyms: 5-Methionine-enkephalin amide TFA)

[Met5]-Enkephalin, amide TFA Chemical Structure

规格 价格 是否有货 数量
10 mg ￥600 In-stock
25 mg ￥1200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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[Met5]-Enkephalin, amide TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

[Met5]-Enkephalin, amide TFA is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

IC50 Target

δ and ζ opioid receptor[1]
体外研究
(In Vitro)

[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

686.70

Formula

C29H37F3N6O8S
Sequence

Tyr-Gly-Gly-Phe-Met-NH2
Sequence Shortening

YGGFM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (145.62 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4562 mL 7.2812 mL 14.5624 mL
5 mM 0.2912 mL 1.4562 mL 2.9125 mL
10 mM 0.1456 mL 0.7281 mL 1.4562 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48.

    [2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.