上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Dehydrocurdione
Dehydrocurdione，一种 zedoary 衍生的倍半萜，在 RAW 264.7 巨噬细胞中诱导血红素加氧酶 (HO)-1，一种抗氧化酶。Dehydrocurdione 与 Keap1 相互作用，导致 Nrf2 易位，随后激活 HO-1 E2 增强子。Dehydrocurdione 抑制脂多糖诱导的 NO 释放，NO 是炎症的标志物。抗炎活性。
Dehydrocurdione Chemical Structure
CAS No. : 38230-32-9
| 规格 | 是否有货 | ||
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| 5 mg | 询价 | ||
| 10 mg | 询价 | ||
| 25 mg | 询价 |
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| 生物活性 |
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2]. |
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| 体外研究 (In Vitro) |
Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
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| 体内研究 (In Vivo) |
Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
234.33 |
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| Formula |
C15H22O2 |
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| CAS 号 |
38230-32-9 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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