天然产物 糖类和糖苷 Saccharides and Glycosides
Thiocolchicoside;(Synonyms: 硫秋水仙苷) 纯度: 99.23%
Thiocolchicoside 是中枢神经系统中竞争性的 γ-氨基丁酸 A 型 (GABAA) 受体拮抗剂和甘氨酸受体激动剂。 Thiocolchicoside 是秋水仙碱的半合成硫衍生物。Thiocolchicoside 是一种肌肉松弛剂,具有抗炎作用,可用于缓解疼痛的研究。
Thiocolchicoside Chemical Structure
CAS No. : 602-41-5
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥500 | In-stock | |
10 mg | ¥800 | In-stock | |
20 mg | ¥1400 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Thiocolchicoside 相关产品
bull;相关化合物库:
- Drug Repurposing Compound Library Plus
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- Immunology/Inflammation Compound Library
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- Glycoside Compound Library
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- FDA Approved amp; Pharmacopeial Drug Library
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- Neurodegenerative Disease-related Compound Library
生物活性 |
Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties[1]. |
IC50 Target |
GABAA) receptor; glycine receptor[1] |
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体外研究 (In Vitro) |
Thiocolchicoside (0.001, 0.1, 1, 10, 100 μM) reduces the amplitude of eIPSCs in a concentration-dependent manner with this effect being significant at 0.1 μM and maximal at 10 μM[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
563.62 |
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Formula |
C27H33NO10S |
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CAS 号 |
602-41-5 |
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中文名称 |
硫秋水仙苷 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : 250 mg/mL (443.56 mM; Need ultrasonic) H2O : 50 mg/mL (88.71 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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