天然产物 黄酮类 Flavonoids
6,8-Diprenylnaringenin (Synonyms: Lonchocarpol A; Senegalensin)
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin) 是一种啤酒花异戊二烯黄酮类化合物,是乳腺癌抗性蛋白 (ABCG2) 的抑制剂。具有一定的雌激素作用,但其效力不到 8-Prenylnaringenin 的 1%。在 HEK293 细胞中抑制 ABCG2 介导的 Mitoxantrone 流出和 3H-Methotrexate 转运 (IC50=0.41 μM)。Prenylnaringenin 具有一定的雌激素作用,但其效力不到 8-Prenylnaringenin 的 1%。
6,8-Diprenylnaringenin Chemical Structure
CAS No. : 68236-11-3
规格 | 是否有货 | ||
---|---|---|---|
5 mg | 询价 | ||
10 mg | 询价 | ||
25 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2]. |
---|---|
分子量 |
408.49 |
Formula |
C25H28O5 |
CAS 号 |
68236-11-3 |
中文名称 |
6,8-二异戊二烯基柚皮素 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
|