Kinetensin;(Synonyms: Kinetensin (human)) 纯度: 99.21%
Kinetensin是从胃蛋白酶处理的人血浆分离的神经降压素 (neurotensin-like) 样肽。
Kinetensin Chemical Structure
CAS No. : 103131-69-7
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥990 | In-stock | |
5 mg | ¥1980 | In-stock | |
10 mg | ¥3190 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Kinetensin 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- GPCR/G Protein Compound Library
- Metabolism/Protease Compound Library
- Neuronal Signaling Compound Library
- Human Endogenous Metabolite Compound Library
- Endocrinology Compound Library
- Peptide Library
生物活性 |
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma. |
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IC50 Target |
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体外研究 (In Vitro) |
The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1172.38 |
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Formula |
C56H85N17O11 |
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CAS 号 |
103131-69-7 |
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Sequence |
Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu |
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Sequence Shortening |
IARRHPYFL |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Protect from light, stored under nitrogen
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen) |
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溶解性数据 |
In Vitro:;
DMSO : 100 mg/mL (85.30 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [2] |
Rat peritoneal mast cells are incubated with kinetensin at 37°C for 10 min. The incubation is stopped by the addition of 1.8 mL of ice-cold buffered saline and cells are separated from supernatant by centrifugation. Histamine release is expressed as per cent of total mast cell histamine[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [2] |
Rats[2] Anesthetized Sprague-Dawley rats are given 25I-albumin i.v. Samples are then injected intradermally in 5×2 spots on the back and comprised saline as a control or kinetensin in different doses in 100 μL saline. After 20 rain, skin biopsies of 7 mm diameter are cut out, weighed and transferred to a gamma-counter. Results are expressed as: (counts per min (cpm) in tissue per gram wet weight/cpm in plasma per mL plasma)[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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