Neuropeptide S (human) (TFA)

Neuropeptide S (human) (TFA);

Neuropeptide S human TFA,一种神经肽,是一种有效的同源神经肽 S 受体 (NPSR) 激动剂。Neuropeptide S human TFA 可用于阿尔茨海默病 (AD) 的研究。

Neuropeptide S (human) (TFA)amp;;

Neuropeptide S (human) (TFA) Chemical Structure

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Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer’s disease (AD) research[1].

IC50 Target

EC50: 9.4 nM (neuropeptide S receptor)[1]

(In Vitro)

Half-maximal effective concentrations (EC50) for mobilization of [Ca2+]i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively[1].
Neuropeptide S (human) (4 pM-1.7 nM; 48 hours) retains full agonist activity with an EC50 of 6.7 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 nM)[1].
Neuropeptide S (human) (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [125II] Y10-NPS, [125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 nM) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(In Vivo)

Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nM or 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6 mice [1]
Dosage: 0.1 nM or 1 nM
Administration: Intracerebroventricular (i.c.v.) injection
Result: Increased locomotor activity and promoted wakefulness.







Sequence Shortening



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  • [1]. Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97.