NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) | Cytiva思拓凡-Whatman滤纸滤膜滤器

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal);

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40) 是 Ape13 的大环类似物，一种有效的 APJ 激动剂 (K_i=5.7 nM)。NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) 表现出有利的 Gα12 偏向信号传导和延长的体内半衰期。

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) Chemical Structure

规格		是否有货
100 mg	;	询价	;
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生物活性	NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (K_i=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life^[1].
IC₅₀ Target	APJ^[1]
分子量	1020.18
Formula	C₄₉H₇₃N₁₃O₁₁
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Tran K, et, al. Size-Reduced Macrocyclic Analogues of [Pyr 1]-apelin-13 Showing Negative Gα 12 Bias Still Produce Prolonged Cardiac Effects. J Med Chem. 2022 Jan 13;65(1):531-551.