标签归档：nh

RLLFT-NH2

发表于由

RLLFT-NH2;

RLLFT-NH2 是一种 TFLLR-NH2 的反向氨基酸序列阴性对照肽。

RLLFT-NH2amp;;

RLLFT-NH2 Chemical Structure

CAS No. : 447408-68-6

规格 是否有货
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生物活性

RLLFT-NH2 is a reversed amino acid sequence negative control peptide for TFLLR-NH2[1].

分子量

647.81

Formula

C31H53N9O6
CAS 号

447408-68-6
Sequence

Arg-Leu-Leu-Phe-Thr-NH2
Sequence Shortening

RLLFT-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Michelle C Buresi, et al. Activation of Proteinase-Activated receptor-1 Inhibits Neurally Evoked Chloride Secretion in the Mouse Colon in Vitro. Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G337-45.

LPYFD-NH2

发表于由

LPYFD-NH2;

LPYFD-NH2 是一种五肽，对 Aβ(1-42) 的聚集具有抑制作用。LPYFD-NH2 可用于阿兹海默症的研究。

LPYFD-NH2amp;;

LPYFD-NH2 Chemical Structure

CAS No. : 700361-48-4

规格 是否有货
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250 mg ; 询价 ;
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生物活性

LPYFD-NH2, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 can be used for the research of Alzheimer’s disease[1].

分子量

652.74

Formula

C33H44N6O8
CAS 号

700361-48-4
Sequence Shortening

LPYFD-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Ilona Laczkó, et al. Aggregation of Abeta(1-42) in the presence of short peptides: conformational studies. J Pept Sci. 2008 Jun;14(6):731-41.

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)

发表于由

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal);

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40) 是 Ape13 的大环类似物，一种有效的 APJ 激动剂 (Ki=5.7 nM)。NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) 表现出有利的 Gα12 偏向信号传导和延长的体内半衰期。

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)amp;;

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) Chemical Structure

规格 是否有货
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生物活性

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (Ki=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life[1].

IC50 Target

APJ[1]
分子量

1020.18

Formula

C49H73N13O11
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tran K, et, al. Size-Reduced Macrocyclic Analogues of [Pyr 1]-apelin-13 Showing Negative Gα 12 Bias Still Produce Prolonged Cardiac Effects. J Med Chem. 2022 Jan 13;65(1):531-551.

LRGILS-NH2

发表于由

LRGILS-NH2;

LRGILS-NH2 是一个反向序列蛋白酶激活受体-2 (PAR-2) 不活跃的，阴性对照。SLIGRL-NH2 则是 PAR-2 激活肽。

LRGILS-NH2amp;;

LRGILS-NH2 Chemical Structure

CAS No. : 245329-01-5

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LRGILS-NH2 的其他形式现货产品:

LRGILS-NH2 TFA

生物活性

LRGILS-NH2 is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide[1].

分子量

656.82

Formula

C29H56N10O7
CAS 号

245329-01-5
Sequence Shortening

LRGILS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nishikawa H, Kawai K, Tanaka M, et al. Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms. J Pharmacol Exp Ther. 2005;312(1):324-331.

Ac-RYYRWK-NH2

发表于由

Ac-RYYRWK-NH2;

Ac-RYYRWK-NH2 是一个有效的和选择性 nociceptin receptor (NOP) 部分激动剂。[3H]Ac-RYYRWK-NH2 结合鼠皮层膜的 Kd 为0.071 nM，但是对 µ-,κ- 或 δ 阿片受体没有亲和力。

Ac-RYYRWK-NH2amp;;

Ac-RYYRWK-NH2 Chemical Structure

CAS No. : 200959-47-3

规格 是否有货
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生物活性

Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].

IC50 Target

Kd: 0.071 nM (ORL1 in rat cortical membranes)[1]
分子量

1012.17

Formula

C2H5KNOWY2
CAS 号

200959-47-3
Sequence Shortening

Ac-RYYRWK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

    [2]. M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.

Ac-RYYRIK-NH2

发表于由

Ac-RYYRIK-NH2;

Ac-RYYRIK-NH2 是一种有效的 ORL1 部分激动剂，作为 ORL1 的内源性配体，在 CHO 细胞中 (Kd=1.5 nM)。Ac-RYYRIK-NH2 是 G 蛋白激活的特异性拮抗剂，竞争性拮抗 noc/OFQ 在大鼠脑膜和脑切面刺激 [35S]-GTPgS 结合 G 蛋白。

Ac-RYYRIK-NH2amp;;

Ac-RYYRIK-NH2 Chemical Structure

CAS No. : 200959-48-4

规格 是否有货
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250 mg ; 询价 ;
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生物活性

Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1].

IC50 Target

Kd: 1.5 nM (ORL1 transfected in CHO cells)[1]
体内研究
(In Vivo)

Ac-RYYRIK-NH2 (intracerebroventricularly (i.c.v.) inhibits spontaneous locomotor activity in mice with an ID50 of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 lead to additive effects in Male Swiss mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

939.11

Formula

C2H5IKNOY2
CAS 号

200959-48-4
Sequence Shortening

Ac-RYYRIK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. H Berger, et al. Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br J Pharmacol. 1999 Feb;126(3):555-8.

    [2]. H Berger, et al. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties.Peptides. 2000 Jul;21(7):1131-9.

    [3]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

LPYFD-NH2 TFA

发表于由

LPYFD-NH2 TFA;

LPYFD-NH2 TFA 是一种五肽，对 Aβ(1-42) 的聚集具有抑制作用。LPYFD-NH2 TFA 可用于阿兹海默症的研究。

LPYFD-NH2 TFAamp;;

LPYFD-NH2 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

LPYFD-NH2 TFA, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 TFA can be used for the research of Alzheimer’s disease[1].

分子量

766.76

Formula

C35H45F3N6O10
Sequence Shortening

LPYFD-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Ilona Laczkó, et al. Aggregation of Abeta(1-42) in the presence of short peptides: conformational studies. J Pept Sci. 2008 Jun;14(6):731-41.

tcY-NH2(Synonyms: (trans-Cinnamoyl)-YPGKF-NH2)

发表于由

tcY-NH2;(Synonyms: (trans-Cinnamoyl)-YPGKF-NH2)

tcY-NH2 是选择性的 PAR4 肽类拮抗剂。tcY-NH2 抑制凝血酶和 AY-NH2 诱导的大鼠血小板聚集。

tcY-NH2amp;;(Synonyms: (trans-Cinnamoyl)-YPGKF-NH2)

tcY-NH2 Chemical Structure

CAS No. : 327177-34-4

规格 是否有货
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生物活性

tcY-NH2 is a selective PAR4 antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH2-induced rat platelet aggregation[1][2].

分子量

739.86

Formula

C40H49N7O7
CAS 号

327177-34-4
Sequence Shortening

{trans-Cinnamoyl}-YPGKF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Morley D Hollenberg, et al. Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol. 2004 Oct;143(4):443-54.

    [2]. L Ma, et al. Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br J Pharmacol. 2001 Oct;134(4):701-4.

K-(D-1-Nal)-FwLL-NH2 TFA

发表于由

K-(D-1-Nal)-FwLL-NH2 TFA;

K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

K-(D-1-Nal)-FwLL-NH2 TFAamp;;

K-(D-1-Nal)-FwLL-NH2 TFA Chemical Structure

规格 是否有货
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500 mg ; 询价 ;

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生物活性

K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

分子量

1016.15

Formula

C53H68F3N9O8
Sequence Shortening

K{Nal}FWLL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

荧光染料L-Biotin-NH-5MP

发表于由

荧光染料Dye Reagents L-Biotin-NH-5MP;

L-Biotin-NH-5MP 是一种生物素偶联的 5-亚甲基吡咯酮 (5MP)。 5-亚甲基吡咯酮 (5MPs) 是一种硫醇特异性的、可逆的生物偶联试剂，可用于半胱氨酸特异性蛋白质修饰，常用于蛋白生物偶联。

L-Biotin-NH-5MP

L-Biotin-NH-5MP Chemical Structure

CAS No. : 2100288-18-2

规格 是否有货
100 mg ; 询价 ;
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500 mg ; 询价 ;

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生物活性

L-Biotin-NH-5MP is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation[1].

分子量

336.41

Formula

C15H20N4O3S
CAS 号

2100288-18-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yingqian Zhang, et al. Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones. J Am Chem Soc. 2017 May 3;139(17):6146-6151.