生化分析试剂 Biochemical Assay Reagents
THK5351; 纯度: 98.41%
THK5351被放射性标记后可作为放射性示踪剂,用于研究大脑中tau病理成像。
THK5351 Chemical Structure
CAS No. : 1707147-26-9
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥1500 | In-stock | |
5 mg | ¥4500 | In-stock | |
10 mg | ¥6500 | In-stock | |
25 mg | ¥12000 | In-stock | |
50 mg | ¥19000 | In-stock | |
100 mg | ; | 询价 | ; |
200 mg | ; | 询价 | ; |
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THK5351 相关产品
bull;相关化合物库:
- Drug Repurposing Compound Library Plus
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
生物活性 |
THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain. |
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体外研究 (In Vitro) |
Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease (AD). 18F-THK5351 binds to Alzheimer disease hippocampal homogenates with high affinity (Kd=2.9 nM; maximum number of binding sites=368.3 pmol/g tissue). It has fast dissociation from white-matter tissue. The THK5351 binding amount correlates with the amount of tau deposits in tissue[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
THK5351 exhibits favorable pharmacokinetics and no defluorination in mice. 18F-THK5351 enters the brain immediately after intravenous injection and shows a fast washout from the brain. At 0.1 and 1 mg/kg, no animals died and no treatment-related changes in any animal are noted in clinical observations, body weight measurement, and pathologic examination[1]. Autoradiography in the brain sections of patients with PSP demonstrates [3H]THK-5351 binding to tau deposits with a high selectivity. Although patients with PSP exhibits no remarkable [18F]THK-5351 retention in the temporal cortex, significantly higher tracer retention is observed in the globus pallidus and midbrain[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
327.35 |
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Formula |
C18H18FN3O2 |
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CAS 号 |
1707147-26-9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : 50 mg/mL (152.74 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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