Polymyxin B nonapeptide TFA

Polymyxin B nonapeptide TFA; 纯度: 99.80%

Polymyxin B nonapeptide TFA 是一种阳离子环肽。Polymyxin B nonapeptide TFA 是经酶裂解 Polymyxin B 而产生的衍生物,与 Polymyxin B 相比,Polymyxin B nonapeptide TFA 毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。

Polymyxin B nonapeptide TFAamp;;

Polymyxin B nonapeptide TFA Chemical Structure

CAS No. : 2220175-42-6

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ¥4220 In-stock
5 mg ¥1500 In-stock
10 mg ¥2500 In-stock
50 mg ¥9500 In-stock
100 mg ¥16500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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Polymyxin B nonapeptide TFA 相关产品


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Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].

(In Vitro)

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.








Room temperature in continental US; may vary elsewhere.


Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

In Vitro:;

H2O : 50 mg/mL (32.61 mM; ultrasonic and warming and heat to 60°C)

浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6522 mL 3.2610 mL 6.5221 mL
5 mM 0.1304 mL 0.6522 mL 1.3044 mL
10 mM 0.0652 mL 0.3261 mL 0.6522 mL


储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

  • [1]. Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92.

    [2]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7.