Ribostamycin sulfate(Synonyms: 硫酸核糖霉素; Vistamycin sulfate)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Ribostamycin sulfate;(Synonyms: 硫酸核糖霉素; Vistamycin sulfate) 纯度: ge;98.0%

Ribostamycin sulfate (Vistamycin sulfate) 是一种广谱抗菌剂, 在30S和50S核糖体亚基结合水平抑制细菌蛋白质合成, 还抑制蛋白二硫键异构酶 (PDI) 分子伴侣活性, 用于药代动力学和肾毒性研究。

Ribostamycin sulfate(Synonyms: 硫酸核糖霉素; Vistamycin sulfate)

Ribostamycin sulfate Chemical Structure

CAS No. : 53797-35-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in Water ￥825 In-stock
50 mg ￥750 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

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生物活性

Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

体外研究
(In Vitro)

Ribostamycin is as an intermediate in the biosynthesis of neomycin[1].
Ribostamycin inhibited the chaperone activity of protein disulfide isomerase (PDI), but it did not inhibit the isomerase activity[3].
Ribostamycin is effective against both gram-positive and gram-negative cocci and bacilli including drug-resistant strains. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

552.55

Formula

C17H36N4O14S
CAS 号

53797-35-6
中文名称

硫酸核糖霉素；核糖霉素硫酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : 130 mg/mL (235.27 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8098 mL 9.0490 mL 18.0979 mL
5 mM 0.3620 mL 1.8098 mL 3.6196 mL
10 mM 0.1810 mL 0.9049 mL 1.8098 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Baud H, et al. Ribostamycin, as an intermediate in the biosynthesis of neomycin. J Antibiot (Tokyo). 1977 Sep;30(9):720-3.

    [2]. Hunfeld KP, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17(3):203-8.

    [3]. Horibe T, et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72.