Spadin TFA

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Spadin TFA; 纯度: 99.73%

Spadin TFA 是一种从血液中释放的前肽衍生的天然肽，能够阻断 TREK-1 (KCNK2 或 K2P2.1) 通道的活性。Spadin TFA 与 TREK-1 特异性结合，亲和力为 10 nM。Spadin TFA 是一种有效的抗抑郁药。

Spadin TFA 

Spadin TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1800 In-stock
5 mg ￥5400 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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Spadin TFA 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Spadin TFA, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin TFA binds specifically to TREK-1 with an affinity of 10 nM. Spadin TFA is an efficient antidepressant in mice[1].

分子量

2126.36

Formula

C92H143F3N26O24
Sequence Shortening

YAPLPRWSGPIGVSWGLR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : 25 mg/mL (11.76 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4703 mL 2.3514 mL 4.7029 mL
5 mM 0.0941 mL 0.4703 mL 0.9406 mL
10 mM 0.0470 mL 0.2351 mL 0.4703 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Jean Mazella, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.