Porcine dynorphin A(1-13)(Synonyms: Dynorphin A Porcine Fragment 1-13)

Porcine dynorphin A(1-13);(Synonyms: Dynorphin A Porcine Fragment 1-13) 纯度: 99.61%

Porcine dynorphin A (1-13) 是一个有效的内源性阿片受体 (κ opioid receptor) 激动剂,在生理浓度下它有缓解疼痛作用。

Porcine dynorphin A(1-13)amp;;(Synonyms: Dynorphin A Porcine Fragment 1-13)

Porcine dynorphin A(1-13) Chemical Structure

CAS No. : 72957-38-1

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1 mg ¥700 In-stock
5 mg ¥1500 In-stock
10 mg ¥2400 In-stock
25 mg ¥4900 In-stock
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Porcine dynorphin A(1-13) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

IC50 Target

Κ opioid receptor[1].

体内研究
(In Vivo)

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1603.96

Formula

C75H126N24O15

CAS 号

72957-38-1

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys

Sequence Shortening

YGGFLRRIRPKLK

中文名称

强啡肽A(1-13),猪

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 60 mg/mL (37.41 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6235 mL 3.1173 mL 6.2346 mL
5 mM 0.1247 mL 0.6235 mL 1.2469 mL
10 mM 0.0623 mL 0.3117 mL 0.6235 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Hauser KF, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75.

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