标签归档：porcine

Secretin, porcine TFA(Synonyms: Porcine secretin TFA)

发表于由

Secretin, porcine TFA;(Synonyms: Porcine secretin TFA)

Secretin, porcine TFA (Porcine secretin TFA) 是由 27 个氨基酸组成的多肽，能够作用于胰腺腺泡细胞和导管上皮细胞，促进富含碳酸氢盐的流体的产生。

Secretin, porcine TFAamp;;(Synonyms: Porcine secretin TFA)

Secretin, porcine TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid[1].

体外研究
(In Vitro)

Secretin, porcine TFA (Porcine secretin TFA) is equivalent to the synthetic porcine and human forms of secretin, and they can be used interchangeably in pancreatic function testing[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3169.43

Formula

C132H221N44F3O43
Sequence

His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2
Sequence Shortening

HSDGTFTSELSRLRDSARLQRLLQGLV-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Somogyi L, et al. Comparison of biologic porcine secretin, synthetic porcine secretin, and synthetic human secretin in pancreatic function testing. Pancreas. 2003 Oct;27(3):230-4.

Neuropeptide Y, porcine TFA

发表于由

Neuropeptide Y, porcine TFA;

Neuropeptide Y, porcine TFA 是存在于猪脑中的多肽，能够抑制分泌素刺激的胰腺分泌。

Neuropeptide Y, porcine TFAamp;;

Neuropeptide Y, porcine TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Neuropeptide Y, porcine TFA, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion[1].

分子量

4253.13

Formula

C190H287N55O57.C2HF3O2
Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. K Tatemoto, et al. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci U S A. 1982 Sep;79(18):5485-9.

Cecropin P1, porcine

发表于由

Cecropin P1, porcine;

Cecropin P1, porcine is an antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.

Cecropin P1, porcineamp;;

Cecropin P1, porcine Chemical Structure

CAS No. : 125667-96-1

规格 价格 是否有货
1 mg ￥2900 询问价格 货期
5 mg ￥6500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Cecropin P1, porcine is an antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.

分子量

3338.86

Formula

C147H253N45O43
CAS 号

125667-96-1
Sequence

Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile-Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg
Sequence Shortening

SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Glucagon (1-29), bovine, human, porcine hydrochloride(Synonyms: 盐酸胰高血糖素 Porcine glucagon hydrochloride)

发表于由

Glucagon (1-29), bovine, human, porcine hydrochloride;(Synonyms: 盐酸胰高血糖素; Porcine glucagon hydrochloride)

Glucagon (1-29), bovine, human, porcine hydrochloride 是由胰腺 α 细胞产生的一种多肽激素。Glucagon (1-29), bovine, human, porcine hydrochloride 促进糖异生。Glucagon (1-29), bovine, human, porcine hydrochloride 可激活 HNF4α 并促进 HNF4α 磷酸化。

Glucagon (1-29), bovine, human, porcine hydrochlorideamp;;(Synonyms: 盐酸胰高血糖素; Porcine glucagon hydrochloride)

Glucagon (1-29), bovine, human, porcine hydrochloride Chemical Structure

CAS No. : 28270-04-4

规格 是否有货
5 mg 询价
10 mg 询价

* Please select Quantity before adding items.

生物活性

Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis[1]. Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation[2][3].

体外研究
(In Vitro)

Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia[1].
Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis[1].
Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes[3].
Glucagon (100 nM) increases phosphorylayion of HNF4α[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: Human primary hepatocytes (H1211, HH1215)
Concentration: 100 nM
Incubation Time:
Result: Resulted in a marked increase in the amount of phosphorylated HNF4α.

体内研究
(In Vivo)

Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (12- to 24-week-old)[4]
Dosage: 20 μg/kg and 1 mg/kg
Administration: Administered by i.p. injection; 45 minutes
Result: Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.
High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion.

分子量

3519.21

Formula

ClH
CAS 号

28270-04-4
Sequence

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
Sequence Shortening

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
中文名称

盐酸胰高血糖素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81.

    [2]. Hirota K, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003 Apr 11;278(15):13056-60.

    [3]. Song KH, et al. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in humanhepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology. 2006 Jan;43(1):117-25.

    [4]. Capozzi ME, et al. Glucagon lowers glycemia when β-cells are active. JCI Insight. 2019 Jul 23;5. pii: 129954.

Neuropeptide Y, porcine

发表于由

Neuropeptide Y, porcine;

Neuropeptide Y, porcine 是存在于猪脑中的多肽，能够抑制分泌素刺激的胰腺分泌。

Neuropeptide Y, porcineamp;;

Neuropeptide Y, porcine Chemical Structure

CAS No. : 83589-17-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Neuropeptide Y, porcine, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion[1].

分子量

4253.13

Formula

C190H287N55O57
CAS 号

83589-17-7
Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. K Tatemoto, et al. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci U S A. 1982 Sep;79(18):5485-9.

Porcine dynorphin A(1-13)(Synonyms: Dynorphin A Porcine Fragment 1-13)

发表于由

Porcine dynorphin A(1-13);(Synonyms: Dynorphin A Porcine Fragment 1-13) 纯度: 99.61%

Porcine dynorphin A (1-13) 是一个有效的内源性阿片受体 (κ opioid receptor) 激动剂，在生理浓度下它有缓解疼痛作用。

Porcine dynorphin A(1-13)amp;;(Synonyms: Dynorphin A Porcine Fragment 1-13)

Porcine dynorphin A(1-13) Chemical Structure

CAS No. : 72957-38-1

规格 价格 是否有货 数量
1 mg ￥700 In-stock
5 mg ￥1500 In-stock
10 mg ￥2400 In-stock
25 mg ￥4900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Porcine dynorphin A(1-13) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

IC50 Target

Κ opioid receptor[1].
体内研究
(In Vivo)

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1603.96

Formula

C75H126N24O15
CAS 号

72957-38-1
Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys
Sequence Shortening

YGGFLRRIRPKLK
中文名称

强啡肽A(1-13),猪
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 60 mg/mL (37.41 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6235 mL 3.1173 mL 6.2346 mL
5 mM 0.1247 mL 0.6235 mL 1.2469 mL
10 mM 0.0623 mL 0.3117 mL 0.6235 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hauser KF, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75.

Elastase from porcine pancreas

发表于由

Elastase from porcine pancreas;

Elastase from porcine pancreas 是具有 240 个氨基酸残基的单条多肽链。Elastase from porcine pancreas 是一种丝氨酸蛋白酶，可以水解蛋白质和多肽。Elastase from porcine pancreas 可诱发仓鼠气肿。

Elastase from porcine pancreasamp;;

Elastase from porcine pancreas Chemical Structure

CAS No. : 39445-21-1

规格 价格 是否有货 数量
5 mg ￥500 In-stock
10 mg ￥800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Elastase from porcine pancreas 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Elastase from porcine pancreas is a single polypeptide chain of 240 amino acid residues. Elastase from porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters[1][2][3].

体内研究
(In Vivo)

Elastase from porcine pancreas induces emphysema in hamsters[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

25898.13

Formula

C1135H1759N331O346S10
CAS 号

39445-21-1
Sequence Shortening

VVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWVMTAAHCVDRELTFRVVVGEHNLNQNNGTEQYVGVQKIVVHPYWNTDDVAAGYDIALLRLAQSVTLNSYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQLAQTLQQAYLPTVDYAICSSSSYWGSTVKNSMVCAGGNGVRSGCQGDSGGPLHCLVNGQYAVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN (Disulfide bridge: Cys30-Cys46; Cys127-Cys194; Cys158- Cys174; Cys184- Cys214)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (1.93 mM; ultrasonic and adjust pH to 9 with NaOH)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.0386 mL 0.1931 mL 0.3861 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Shotton DM, et, al. Amino-acid sequence of porcine pancreatic elastase and its homologies with other serine proteinases. Nature. 1970 Feb 28;225(5235):802-6.

    [2]. Teshima T, et, al. A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates. J Biol Chem. 1982 May 10;257(9):5085-91.

    [3]. Stone PJ, et, al. Induction and exacerbation of emphysema in hamsters with human neutrophil elastase inactivated reversibly by a peptide boronic acid. Am Rev Respir Dis. 1990 Jan;141(1):47-52.