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Cecropin P1, porcine

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Cecropin P1, porcine;

Cecropin P1, porcine is an antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.

Cecropin P1, porcineamp;;

Cecropin P1, porcine Chemical Structure

CAS No. : 125667-96-1

规格 价格 是否有货
1 mg ￥2900 询问价格 货期
5 mg ￥6500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Cecropin P1, porcine is an antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.

分子量

3338.86

Formula

C147H253N45O43
CAS 号

125667-96-1
Sequence

Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile-Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg
Sequence Shortening

SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Allergen Der p2 (Mite) (rec.) (His) 过敏原 Der p2（螨）（重组）（His标签） 品牌：AbFrontier

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Allergen Der p2 (Mite) (rec.) (His)

过敏原 Der p2（螨）（重组）（His标签）

品牌：AbFrontier
CAS No.：
储存条件：-80°C
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

YIF-LF-P0526

 – 0.1 mg –

Allergen Der p2 (Mite) (rec.) (His) 过敏原 Der p2（螨）（重组）（His标签） 品牌：AbFrontier

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Allergen Der p2 (Mite) (rec.) (His) 过敏原 Der p2（螨）（重组）（His标签） 品牌：AbFrontier

发表于由

Allergen Der p2 (Mite) (rec.) (His)

过敏原 Der p2（螨）（重组）（His标签）

品牌：AbFrontier
CAS No.：
储存条件：-80°C
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

YIF-LF-P0526A

 – 0.5 mg –

Allergen Der p2 (Mite) (rec.) (His) 过敏原 Der p2（螨）（重组）（His标签） 品牌：AbFrontier

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Allergen Der p2 (Mite) (rec.) (His) 过敏原 Der p2（螨）（重组）（His标签） 品牌：AbFrontier

发表于由

Allergen Der p2 (Mite) (rec.) (His)

过敏原 Der p2（螨）（重组）（His标签）

品牌：AbFrontier
CAS No.：
储存条件：-80°C
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

YIF-LF-P0526B

 – 1 mg –

Allergen Der p2 (Mite) (rec.) (His) 过敏原 Der p2（螨）（重组）（His标签） 品牌：AbFrontier

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Phosphoinositide 3-Kinase p110 gamma, Human, recombinant, Solution 磷脂酰肌醇3激酶 品牌：FUJIFILM Wako

发表于由

Phosphoinositide 3-Kinase p110 gamma, Human, recombinant, Solution

磷脂酰肌醇3激酶

品牌：FUJIFILM Wako
CAS No.：
储存条件： –
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

168-20531

 – 10 ug(10 ul) –

Phosphoinositide 3-Kinase p110 gamma, Human, recombinant, Solution 磷脂酰肌醇3激酶 品牌：FUJIFILM Wako

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

HIV p17 Gag (77-85)

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HIV p17 Gag (77-85);

HIV p17 Gag (77-85) 是一种 HLA-A*0201(A2)-限制性 CTL 表位，用于抗 HIV 的研究。

HIV p17 Gag (77-85)amp;;

HIV p17 Gag (77-85) Chemical Structure

CAS No. : 147468-65-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

HIV p17 Gag (77-85) is an HLA-A*0201(A2)-restricted CTL epitope, used in the research of anti-HIV[1].

分子量

981.10

Formula

C44H72N10O15
CAS 号

147468-65-3
Sequence

Ser-Leu-Tyr-Asn-Thr-Val-Ala-Thr-Leu
Sequence Shortening

SLYNTVATL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kan-Mitchell J, et al. Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL response. J Immunol. 2006 Jun 1;176(11):6690-701.

LyP-1

发表于由

LyP-1;

LyP-1 是一种环状 9 个氨基酸的肿瘤的定位肽，在多种肿瘤相关细胞中，选择性结合其 p32 receptor 蛋白。

LyP-1amp;;

LyP-1 Chemical Structure

CAS No. : 454487-07-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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LyP-1 的其他形式现货产品:

LyP-1 TFA

生物活性

LyP-1 is a cyclic 9‐amino‐acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells[1].

体内研究
(In Vivo)

LyP-1 (8 weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide[1].
The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.
At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×106 photon/cm2/sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

992.14

Formula

C36H65N17O12S2
CAS 号

454487-07-1
Sequence Shortening

CGNKRTRGC (Disulfide bridge: Cys1-Cys9)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fan Zhang, et al.Imaging tumor-induced sentinel lymph node lymphangiogenesis with LyP-1 peptide. Amino Acids. 2012 Jun;42(6):2343-51.

    [2]. Ningning Song, et al. Recent progress in LyP-1-based strategies for targeted imaging and therapy. Drug Deliv. 2019 Dec;26(1):363-375.

TAT-P4-(DATC5)2 TFA

发表于由

TAT-P4-(DATC5)2 TFA;

TAT-P4-(DATC5)2 TFA 是一种蛋白激酶 C 相互作用蛋白 1 PDZ 结构域 (PICK1 PDZ domain) 的高亲和力多肽抑制剂，其 Ki 值为 1.7 nM。TAT-P4-(DATC5)2 TFA 能抑制大鼠可卡因上瘾。

TAT-P4-(DATC5)2 TFAamp;;

TAT-P4-(DATC5)2 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

TAT-P4-(DATC5)2 TFA is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 TFA attenuats the reinstatement of cocaine seeking in rats[1].

IC50 Target

Ki: 1.7 nM (PICK1 PDZ domain)[1]
体内研究
(In Vivo)

TAT-P4-(DATC5)2 TFA (0.99 μg/kg, 9.9 μg/kg; Infused intravenously) dose-dependently attenuats the reinstatement of cocaine seeking in rats at doses that do not produce operant learning deficits or suppress locomotor activity [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) [1]
Dosage: 0.99 μg/kg, 9.9 μg/kg
Administration: Infused intravenously, 45 min prior to an acute injection of cocaine (10 mg/kg, i.p.)
Result: Attenuated the reinstatement of cocaine seeking in rats.

分子量

3403.97

Formula

C16H25F3O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Christopher Turner, et al. Administration of a Novel High Affinity PICK1 PDZ Domain Inhibitor Attenuates Cocaine Seeking in Rats. Neuropharmacology. 2020 Mar 1;164:107901.

Gliadin p31-43 TFA

发表于由

Gliadin p31-43 TFA;

Gliadin p31-43 TFA 是一种未消化的麦醇溶蛋白肽，可诱导肠道内的先天性免疫反应并干扰内吞运输。Gliadin p31-43 TFA 可用于乳糜泻的研究。

Gliadin p31-43 TFAamp;;

Gliadin p31-43 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Gliadin p31-43 TFA 的其他形式现货产品:

Gliadin p31-43

生物活性

Gliadin p31-43 TFA is an undigested gliadin peptide. Gliadin p31-43 TFA induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 TFA can be used for celiac disease research[1][2].

体外研究
(In Vitro)

Gliadin p31-43 (100 μg/mL; 30 minutes-6 hours) treatment induces the MyD88/TLR7 complexes, and activates downstream signalling by activating MAPKs, ERK, JNK and p38). Gliadin p31-43 increases the levels of the phosphorylated forms of pY-ERK, JNK (pY-JNK) and p38 (pY-p38)[1].
Gliadin p31-43 treatment increases NF-κB phosphorylation in CaCo-2 cells from 0.45 in control cells to 0.86. Gliadin p31-43 treatment induces a significant increase in levels of the MxA protein. The levels of the IFN-α 7 and 17 mRNAs are also analysed after Gliadin p31-43 treatment[1].
In CaCo-2 cells, Gliadin p31-43 localizes to the early endosomes and delays vesicular trafficking. Gliadin p31-43 interferes with the correct localization of the growth factor regulated tyrosine kinase substrate (HRS) to early endosomes, delaying the maturation of the endocytic vesicles[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: CaCo-2 cells
Concentration: 100 μg/mL
Incubation Time: 30 minutes, 3 hours, 6 hours
Result: Showed the increase in formation of the MyD88/TLR7 complex, and increased in the level of TLR7.

体内研究
(In Vivo)

Gliadin p31-43 (10 μg; intraluminally injection) shows a sequence-specific spontaneous ability to form structured oligomers and aggregates in vitro and induced activation of the apoptosis-associated speck-like (ASC) complex[2].
The increment of IL-1β indicates the activation of the inflammasome caspase-1 pathway in the small intestine mucosa by oral administration of Gliadin p31-43 (20 μg) in wild type C57Bl/6 mice. Gliadin p31-43 has an intrinsic propensity to form oligomers which trigger the NLRP3 inflammasome[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1641.70

Formula

C73H103F3N18O22
Sequence Shortening

LGQQQPFPPQQPY
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Merlin Nanayakkara, et al. P31-43, an undigested gliadin peptide, mimics and enhances the innate immune response to viruses and interferes with endocytic trafficking: a role in celiac disease. Sci Rep. 2018 Jul 17;8(1):10821.

    [2]. María Florencia Gómez Castro, et al. p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine. Front Immunol. 2019 Jan 30;10:31.

Peripheral Myelin Protein P2 (53-78), bovine

发表于由

Peripheral Myelin Protein P2 (53-78), bovine;

Peripheral Myelin Protein P2 (53-78), bovine 是源自牛外周髓磷脂 P2 蛋白氨基酸残基 53-78。Peripheral Myelin Protein P2 (53-78), bovine 是一种 T 细胞抗原表位，可在 Lewis 大鼠中诱导实验性自身免疫性神经炎 (EAN)。

Peripheral Myelin Protein P2 (53-78), bovineamp;;

Peripheral Myelin Protein P2 (53-78), bovine Chemical Structure

CAS No. : 81628-50-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Peripheral Myelin Protein P2 (53-78), bovine is derived from bovine peripheral myelin P2 protein amino acid residues 53-78. Peripheral Myelin Protein P2 (53-78), bovine is a T cell epitope for the induction of experimental autoimmune neuritis (EAN) in Lewis rats[1].

分子量

3019.19

Formula

C131H200N34O48
CAS 号

81628-50-4
Sequence

Thr-Glu-Ser-Pro-Phe-Lys-Asn-Thr-Glu-Ile-Ser-Phe-Lys-Leu-Gly-Gln-Glu-Phe-Glu-Glu-Thr-Thr-Ala-Asp-Asn-Arg
Sequence Shortening

TESPFKNTEISFKLGQEFEETTADNR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. A Rostami, et al. Peptide 53-78 of myelin P2 protein is a T cell epitope for the induction of experimental autoimmune neuritis. Cell Immunol. 1991 Feb;132(2):433-41.