标签归档：phe

Boc-Gly-Gly-Phe-Gly-OH TFA

发表于由

Boc-Gly-Gly-Phe-Gly-OH TFA; 纯度: 98.27%

Boc-Gly-Gly-Phe-Gly-OH TFA 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

Boc-Gly-Gly-Phe-Gly-OH TFAamp;;

Boc-Gly-Gly-Phe-Gly-OH TFA Chemical Structure

规格 价格 是否有货 数量
10 mg ￥900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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生物活性

Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

IC50 Target

Cleavable

;

分子量

550.48

Formula

C22H29F3N4O9
Sequence Shortening

Boc-GGFG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 125 mg/mL (227.07 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8166 mL 9.0830 mL 18.1660 mL
5 mM 0.3633 mL 1.8166 mL 3.6332 mL
10 mM 0.1817 mL 0.9083 mL 1.8166 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

[(pF)Phe4]Nociceptin(1-13)NH2

发表于由

[(pF)Phe4]Nociceptin(1-13)NH2;

[(pF)Phe4]Nociceptin(1-13)NH2 是一种高效、选择性的 NOP 受体 (OP4) 激动剂，pKi 为 10.68，pEC50 为 9.31。[(pF)Phe4]Nociceptin(1-13)NH2 对 δ、κ 和 μ 阿片受体具有较高的选择性 (>3000 倍)。

[(pF)Phe4]Nociceptin(1-13)NH2amp;;

[(pF)Phe4]Nociceptin(1-13)NH2 Chemical Structure

CAS No. : 380620-88-2

规格 是否有货
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250 mg ; 询价 ;
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生物活性

[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold)[1][2].

体内研究
(In Vivo)

In unanaesthetised normotensive mice, bolus intravenous injection of 100 nmol/kg of [(pF)Phe4]Nociceptin(1-13)NH2 decreases mean blood pressure and heart rate; these effects are longer lasting than those elicited by the same dose of NC(1-13)NH2. I.c.v. administration of [(pF)Phe4]Nociceptin(1-13)NH2 dose-dependently stimulated feeding in rats, and is about tenfold more potent than NC(1-13)NH2[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1399.58

Formula

C61H99FN22O15
CAS 号

380620-88-2
Sequence Shortening

FGG{Phe(4-F)}TGARKSARK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rizzi A, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):450-456.

    [2]. Bigoni R, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):442-449.

    [3]. Guerrini R, et al. Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J Med Chem. 2001;44(23):3956-3964.

Fmoc-Phe-Ser(psi(Me,Me)pro)-OH

发表于由

Fmoc-Phe-Ser(psi(Me,Me)pro)-OH;

Fmoc-Phe-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Phe-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Phe-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 878797-01-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
100 mg ￥500 In-stock
500 mg ￥1200 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

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Fmoc-Phe-Ser(psi(Me,Me)pro)-OH 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Fmoc-Phe-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

514.57

Formula

C30H30N2O6
CAS 号

878797-01-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

DMSO : 250 mg/mL (485.84 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9434 mL 9.7169 mL 19.4337 mL
5 mM 0.3887 mL 1.9434 mL 3.8867 mL
10 mM 0.1943 mL 0.9717 mL 1.9434 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (4.04 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.04 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.04 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.04 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

H-D-Phe-Pip-Arg-pNA(Synonyms: S-2238)

发表于由

H-D-Phe-Pip-Arg-pNA;(Synonyms: S-2238)

H-D-Phe-Pip-Arg-pNA (S-2238) 是一种显色底物，在凝血酶的天然底物纤维蛋白原 α 链的 N 端部分之后形成。H-D-Phe-Pip-Arg-pNA 对凝血酶有特异性，用于测定抗凝血酶肝素辅因子 (AT-III)。使用 H-D-Phe-Pip-Arg-pNA 进行的 AT-III 分析灵敏、准确、易于执行。

H-D-Phe-Pip-Arg-pNAamp;;(Synonyms: S-2238)

H-D-Phe-Pip-Arg-pNA Chemical Structure

CAS No. : 64815-81-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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H-D-Phe-Pip-Arg-pNA 的其他形式现货产品:

H-D-Phe-Pip-Arg-pNA acetate

生物活性

H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform[1][2].

分子量

552.63

Formula

C27H36N8O5
CAS 号

64815-81-2
Sequence Shortening

{D-Phe}-{Pip}-R-pNA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647.

    [2]. Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353.

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

发表于由

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA;(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) 是一种甲酰肽受体 (FPR) 激动剂。

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFAamp;;(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA 的其他形式现货产品:

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys

生物活性

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist[1].

IC50 Target

Formyl peptide receptor[1]
分子量

938.04

Formula

C45H66F3N7O11
Sequence

N-Formyl-{NLE}-Leu-Phe-{NLE}-Tyr-Lys
Sequence Shortening

N-Formyl-{NLE}-LF-{NLE}-YK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Stenfeldt AL, et al. The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptidereceptor but not the formyl peptide receptor like 1. Biochem Pharmacol. 2007 Oct 1;74(7):1050-6.

{Boc}-Phe-Leu-Phe-Leu-Phe TFA

发表于由

{Boc}-Phe-Leu-Phe-Leu-Phe TFA;

{Boc}-Phe-Leu-Phe-Leu-Phe TFA 是一种甲酰肽受体 (FPR) 家族拮抗剂，可优先抑制通过甲酰肽受体触发的活性。

{Boc}-Phe-Leu-Phe-Leu-Phe TFAamp;;

{Boc}-Phe-Leu-Phe-Leu-Phe TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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生物活性

{Boc}-Phe-Leu-Phe-Leu-Phe TFA is a formyl peptide receptor (FPR) family antagonist that preferentially inhibits activity triggered through the formyl peptide receptor[1].

分子量

899.99

Formula

C46H60F3N5O10
Sequence Shortening

{Boc}-FLFLF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anna-Lena Stenfeldt, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9.

[D-p-Cl-Phe6,Leu17]-VIP

发表于由

[D-p-Cl-Phe6,Leu17]-VIP;

[D-p-Cl-Phe6,Leu17]-VIP 是一种竞争性和选择性的血管活性肠肽 (VIP) 受体拮抗剂，IC50 值为 125.8 nM。[D-p-Cl-Phe6,Leu17]-VIP 对胰高血糖素，促胰液素和 GRF 受体无活性。

[D-p-Cl-Phe6,Leu17]-VIPamp;;

[D-p-Cl-Phe6,Leu17]-VIP Chemical Structure

CAS No. : 102805-45-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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[D-p-Cl-Phe6,Leu17]-VIP 的其他形式现货产品:

[D-p-Cl-Phe6,Leu17]-VIP TFA

生物活性

[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3].

IC50 Target

IC50: 125.8 nM (VIP receptor)[1]
分子量

3342.20

Formula

C148H239ClN44O42
CAS 号

102805-45-8
Sequence

His-Ser-Asp-Ala-Val-{Cl-Phe}-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Sequence Shortening

HSDAV-{Cl-Phe}-TDNYTRLRKQLAVKKYLNSILN-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86.

    [2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7.

    [3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH

发表于由

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH;

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Phe-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 1196703-48-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

528.60

Formula

C31H32N2O6
CAS 号

1196703-48-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

{Boc}-Phe-Leu-Phe-Leu-Phe

发表于由

{Boc}-Phe-Leu-Phe-Leu-Phe;

{Boc}-Phe-Leu-Phe-Leu-Phe ({Boc}-FLFLF) 是一种甲酰肽受体 (FPR) 家族拮抗剂，可优先抑制通过甲酰肽受体触发的活性。

{Boc}-Phe-Leu-Phe-Leu-Pheamp;;

{Boc}-Phe-Leu-Phe-Leu-Phe Chemical Structure

CAS No. : 66556-73-8

规格 价格 是否有货
1 mg ￥2500 询问价格 货期
5 mg ￥6000 询问价格 货期
10 mg ￥10000 询问价格 货期

* Please select Quantity before adding items.

生物活性

{Boc}-Phe-Leu-Phe-Leu-Phe ({Boc}-FLFLF) is a formyl peptide receptor (FPR) family antagonist that preferentially inhibits activity triggered through the formyl peptide receptor[1].

分子量

785.97

Formula

C44H59N5O8
CAS 号

66556-73-8
Sequence Shortening

{Boc}-FLFLF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Anna-Lena Stenfeldt, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9.

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa

发表于由

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa;

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa 是一种来源 snail Helix aspersa 内脏和躯干肌肉的 FMRF 样肽。FMRF 是由 4 个氨基残基构成的神经肽。

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersaamp;;

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa Chemical Structure

CAS No. : 98495-35-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues[1].

分子量

904.02

Formula

C44H61N11O10
CAS 号

98495-35-3
Sequence

{pGLU}-Asp-Pro-Phe-Leu-Arg-Phe
Sequence Shortening

{pGLU}-DPFLRF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Lehman HK, et al. The actions of FMRFamide-like peptides on visceral and somatic muscles of the snail Helix aspersa. J Exp Biol. 1987 Sep;131:55-68.