Boc-Gly-Gly-Phe-Gly-OH

发表于2024年5月8日由Whatman官网

Boc-Gly-Gly-Phe-Gly-OH; 纯度: 99.10%

Boc-Gly-Gly-Phe-Gly-OH 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

Boc-Gly-Gly-Phe-Gly-OH Chemical Structure

CAS No. : 187794-49-6

规格	价格	是否有货	数量
Free Sample (0.1-0.5 mg)	;	Apply now	;
10 mg	￥900	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

IC₅₀ Target

Cleavable

;

分子量

436.46

Formula

C₂₀H₂₈N₄O₇

CAS 号

187794-49-6

Sequence Shortening

Boc-GGFG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : ≥ 100 mg/mL (229.12 mM)

H₂O : 25 mg/mL (57.28 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2912 mL	11.4558 mL	22.9116 mL
5 mM	0.4582 mL	2.2912 mL	4.5823 mL
10 mM	0.2291 mL	1.1456 mL	2.2912 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：;PBS

Solubility: 36.67 mg/mL (84.02 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (5.73 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.73 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.73 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.73 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

Z-Gly-Gly-Arg-AMC acetate

发表于2024年5月3日由Whatman官网

Z-Gly-Gly-Arg-AMC acetate; 纯度: 98.58%

Z-Gly-Gly-Arg-AMC acetate 是凝血素特异性的荧光底物，可用于检测 PRP 和缺乏血小板血浆中凝血酶的生成。

Z-Gly-Gly-Arg-AMC acetate Chemical Structure

CAS No. : 2070009-61-7

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥1393	In-stock
5 mg	￥990	In-stock
10 mg	￥1400	In-stock
50 mg	￥4000	In-stock
100 mg	;	询价	;
200 mg	;	询价	;

* Please select Quantity before adding items.

Z-Gly-Gly-Arg-AMC acetate 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

分子量

639.66

Formula

C₃₀H₃₇N₇O₉

CAS 号

2070009-61-7

Sequence

Z-Gly-Gly-Arg-AMC

Sequence Shortening

ZGGR-AMC

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:;

DMSO : 500 mg/mL (781.67 mM; Need ultrasonic)

H₂O : 20 mg/mL (31.27 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5633 mL	7.8167 mL	15.6333 mL
5 mM	0.3127 mL	1.5633 mL	3.1267 mL
10 mM	0.1563 mL	0.7817 mL	1.5633 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 4.17 mg/mL (6.52 mM); Clear solution

此方案可获得 ≥ 4.17 mg/mL (6.52 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 4.17 mg/mL (6.52 mM); Clear solution

此方案可获得 ≥ 4.17 mg/mL (6.52 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 4.17 mg/mL (6.52 mM); Clear solution

此方案可获得 ≥ 4.17 mg/mL (6.52 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Tarandovskiy ID, et al. Antiplatelet agents can promote two-peaked thrombin generation in platelet rich plasma: mechanism and possible applications. PLoS One. 2013;8(2):e55688.

[2]. Machlus KR, et al. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost. 2009 Nov;102(5):936-44.

Arg-Gly-Asp-Ser(Synonyms: RGDS peptide Fibronectin tetrapeptide)

发表于2024年4月30日由Whatman官网

Arg-Gly-Asp-Ser;(Synonyms: RGDS peptide; Fibronectin tetrapeptide) 纯度: 99.76%

Arg-Gly-Asp-Ser 是整联蛋白结合序列，抑制整联蛋白受体 (integrin receptor) 功能。Arg-Gly-Asp-Ser 直接并特异性地结合 pro-caspase-8，pro-caspase-9 和 pro-caspase-3，但不与 pro-caspase-1 结合。

Arg-Gly-Asp-Seramp;;(Synonyms: RGDS peptide; Fibronectin tetrapeptide)

Arg-Gly-Asp-Ser Chemical Structure

CAS No. : 91037-65-9

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥610	In-stock
10 mg	￥550	In-stock
50 mg	￥1750	In-stock
100 mg	￥3150	In-stock
200 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

Arg-Gly-Asp-Ser 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Peptidomimetic Library
Cytoskeleton Compound Library
Targeted Diversity Library
Peptide Library

生物活性

Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

体外研究
(In Vitro)

The Arg-Gly-Asp-Ser-modified surface causes up-regulation of αvβ3 integrin. Attachment to the Arg-Gly-Asp-Ser-treated membrane completely abolishes apoptosis induced by staurosporine, the Ca²⁺·Pi ion pair, and sodium nitroprusside. Arg-Gly-Asp-Ser-dependent resistance to apoptosis is eliminated, when the activity of the phosphatidylinositol 3-kinase pathway is inhibited^[1]. Arg-Gly-Asp-Ser interacts with survivin, as well as with procaspase-3, -8 and -9. Arg-Gly-Asp-Ser-peptide binding to survivin is found to be specific, at high affinity (K_d 27.5 μM) and locates at the survivin C-terminus. Arg-Gly-Asp-Ser-survivin interaction appears to play a key role, since Arg-Gly-Asp-Ser lost its anti-mitogenic effect in survivin-deprived cells with a specific siRNA^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Arg-Gly-Asp-Ser (2.5 or 5 mg/kg, 1 h before LPS) significantly inhibits LPS-induced MMP-9 activity in BAL fluid 4 h post-LPS. Arg-Gly-Asp-Ser (1, 2.5 or 5 mg/kg, i.p.) administers 1 h before LPS inhibited LPS-induced increases in TNF-α and MIP-2 levels in BAL fluid at 4 h post-LPS^[2]. Arg-Gly-Asp-Ser peptide significantly reduces tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP)-2 production, and decreases myeloperoxidase (MPO) and NF-κB activity^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

433.42

Formula

C₁₅H₂₇N₇O₈

CAS 号

91037-65-9

Sequence

Arg-Gly-Asp-Ser

Sequence Shortening

RGDS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

DMSO : ≥ 55 mg/mL (126.90 mM)

H₂O : ≥ 25 mg/mL (57.68 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3072 mL	11.5362 mL	23.0723 mL
5 mM	0.4614 mL	2.3072 mL	4.6145 mL
10 mM	0.2307 mL	1.1536 mL	2.3072 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Grigoriou V, et al. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J Biol Chem. 2005 Jan 21;280(3):1733-9.

[2]. Moon C, et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res. 2009 Mar 9;10:18.

[3]. Yin X, et al. Synthetic RGDS peptide attenuated lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure in mice. J Gastroenterol Hepatol. 2014 Jun;29(6):1308-15.

[4]. Aguzzi MS, et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer. 2010 Apr 22;9:84.

Cell Assay ^[1]	Cell death is measured using the MTT analysis. This assay is based on the ability of mitochondrial dehydrogenases to oxidize thiazolyl blue (MTT), a tetrazolium salt (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenylterazolium bromide), to an insoluble blue formazan product. The cells are incubated with the MTT reagent (120 μg/mL) at 37°C for 2 h. After the supernatant is removed, 400 μL of 0.04mol/LHCl in isopropanol is added to each well, and the optical density of the solution is read at 590 nm in an enzyme-linked immunosorbent assay plate reader. As the generation of the blue product is proportional to the dehydrogenase activity, a decrease in the absorbance at 590 nm provides a direct measurement of the number of viable cells. To determine the contribution of the PI3K pathway to inhibition of apoptosis, some cell populations are pretreated with 50 μM LY294002, a PI3K inhibitor. Following this pretreatment, cell death is determined as described above. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[2]	Mice pharyngeal aspiration is performed as described. Animals are anesthetized with a mixture of ketamine and xylazine (45 mg/kg and 8 mg/kg, i.p., respectively). Test solution (30 μL) containing LPS (1.5 mg/kg) is placed posterior in the throat and aspirated into the lungs. Control mice are administrated sterile saline (0.9% NaCl). Animals are administered with Arg-Gly-Asp-Ser or RGES peptide (1, 2.5 or 5 mg/kg, i.p.) once one hour before LPS treatment and sacrificed 4 h post-LPS. Animals are also administered Arg-Gly-Asp-Ser or RGES peptide (5 mg/kg, i.p.) once at different time points (1 h before or 2 h after LPS treatment) and sacrificed 24 h post-LPS. In addition, animals are administered with αvβ3-blocking mAbs, anti-αv, or anti-β3 (5 mg/kg, i.p.) once 1 h before and sacrificed 4 h post-LPS. Animals administered with these mAbs 2 h after LPS treatment are sacrificed 24 h post-LPS MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Grigoriou V, et al. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J Biol Chem. 2005 Jan 21;280(3):1733-9. [2]. Moon C, et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res. 2009 Mar 9;10:18. [3]. Yin X, et al. Synthetic RGDS peptide attenuated lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure in mice. J Gastroenterol Hepatol. 2014 Jun;29(6):1308-15. [4]. Aguzzi MS, et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer. 2010 Apr 22;9:84.

Gly-Arg-Gly-Asp-Ser

发表于2024年4月28日由Whatman官网

Gly-Arg-Gly-Asp-Ser; 纯度: 95.05%

Gly-Arg-Gly-Asp-Ser 是一种五肽，构成了糖蛋白，骨桥蛋白与细胞的结合域。

Gly-Arg-Gly-Asp-Ser Chemical Structure

CAS No. : 96426-21-0

规格	价格	是否有货	数量
2 mg	￥550	In-stock
5 mg	￥1100	In-stock
10 mg	￥1650	In-stock
25 mg	￥3300	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Gly-Arg-Gly-Asp-Ser 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptidomimetic Library
Peptide Library

生物活性

Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM^[1]

IC₅₀ Target

IC50: 5 μM (αvβ3), 6.5 μM (αvβ5)^[2]

体外研究
(In Vitro)

Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC₅₀ of 5 μM^[1]. Gly-Arg-Gly-Asp-Ser-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

490.47

Formula

C₁₇H₃₀N₈O₉

CAS 号

96426-21-0

Sequence

Gly-Arg-Gly-Asp-Ser

Sequence Shortening

GRGDS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (203.89 mM; Need ultrasonic)

H₂O : 33.33 mg/mL (67.96 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0389 mL	10.1943 mL	20.3886 mL
5 mM	0.4078 mL	2.0389 mL	4.0777 mL
10 mM	0.2039 mL	1.0194 mL	2.0389 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.10 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.10 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.10 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997.

[2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.

Tyr-Gly-Gly-Phe-Met-OH(Synonyms: 蛋氨酸脑啡肽 Met-Enkephalin Methionine enkephalin)

发表于2024年4月24日由Whatman官网

Tyr-Gly-Gly-Phe-Met-OH;(Synonyms: 蛋氨酸脑啡肽; Met-Enkephalin; Methionine enkephalin) 纯度: 98.07%

Tyr-Gly-Gly-Phe-Met-OH 通过结合阿片样物质受体 (opioid receptor)，可调控人类免疫功能，抑制肿瘤生长。

Tyr-Gly-Gly-Phe-Met-OHamp;;(Synonyms: 蛋氨酸脑啡肽; Met-Enkephalin; Methionine enkephalin)

Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

CAS No. : 58569-55-4

规格	价格	是否有货	数量
Free Sample (0.1-0.5 mg)	;	Apply now	;
10;mM;*;1 mL in Water	￥550	In-stock
10 mg	￥500	In-stock
25 mg	￥950	In-stock
50 mg	￥1600	In-stock
100 mg	￥2600	In-stock
200 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

Tyr-Gly-Gly-Phe-Met-OH 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Neuronal Signaling Compound Library
Anti-Cancer Compound Library
Peptidomimetic Library
Neurotransmitter Receptor Compound Library
Rare Diseases Drug Library
Peptide Library

生物活性

Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

IC₅₀ Target

Opioid Receptor^[1].

体外研究
(In Vitro)

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

573.66

Formula

C₂₇H₃₅N₅O₇S

CAS 号

58569-55-4

Sequence

Tyr-Gly-Gly-Phe-Met

Sequence Shortening

YGGFM

中文名称

蛋氨酸脑啡肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : ≥ 40 mg/mL (69.73 mM)

H₂O : 6.67 mg/mL (11.63 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7432 mL	8.7160 mL	17.4319 mL
5 mM	0.3486 mL	1.7432 mL	3.4864 mL
10 mM	0.1743 mL	0.8716 mL	1.7432 mL

参考文献

[1]. Zhao D, et al. Methionine enkephalin, its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9.

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA

发表于2024年4月22日由Whatman官网

生化分析试剂 Biochemical Assay Reagents
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA; 纯度: ge;98.0%

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA 可用于检测 P. falciparum 时期 N-肉豆蔻酰化和 GPI 锚定蛋白的修饰位点。

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA Chemical Structure

规格	价格	是否有货	数量
25 mg	￥18500	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus

生物活性

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum^[1].

分子量

970.07

Formula

C₃₈H₆₆F₃N₁₃O₁₁S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (103.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0309 mL	5.1543 mL	10.3085 mL
5 mM	0.2062 mL	1.0309 mL	2.0617 mL
10 mM	0.1031 mL	0.5154 mL	1.0309 mL

参考文献

[1]. Malgorzata Broncel, et al. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. Angew Chem Int Ed Engl. 2015 May 11;54(20):5948-51.

H-Gly-Pro-OH

发表于2024年4月20日由Whatman官网

H-Gly-Pro-OH; 纯度: ge;97.0%

H-Gly-Pro-OH 是胶原蛋白代谢的最终产物，它会进一步被脯氨肽酶进一步裂解。

H-Gly-Pro-OH Chemical Structure

CAS No. : 704-15-4

规格	价格	是否有货	数量
100 mg	￥500	In-stock
200 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

H-Gly-Pro-OH 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Natural Product Library
Human Endogenous Metabolite Compound Library
Peptidomimetic Library
Food-Sourced Compound Library
Peptide Library

生物活性

H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.

IC₅₀ Target

Human Endogenous Metabolite

;

分子量

172.18

Formula

C₇H₁₂N₂O₃

CAS 号

704-15-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 1 mg/mL (5.81 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.8079 mL	29.0394 mL	58.0788 mL
5 mM	1.1616 mL	5.8079 mL	11.6158 mL
10 mM	—	—	—

参考文献

[1]. Le J, et al. Urine glycyl-L-proline increase and skin trophicity. Amino Acids. 1999;17(3):315-22.

加拿大Silicycle硅胶填料SiliaBond Glycidoxy (GLY) nec (R36030B)

发表于2024年3月25日由Whatman官网

上海金畔生物科技有限公司代理加拿大Silicycle硅胶填料色谱柱层析板金属离子清除剂全线产品，欢迎访问官网了解更多产品信息和订购。

SiliaBond Glycidoxy (GLY) nec (R36030B)

Prices do not include applicable taxes, customs, duties and/or shipping.

Product Number	Quantity
R36030B-10G	10 g	具体价格咨询客服
R36030B-25G	25 g	具体价格咨询客服
R36030B-50G	50 g	具体价格咨询客服
R36030B-100G	100 g	具体价格咨询客服
R36030B-250G	250 g	具体价格咨询客服
R36030B-500G	500 g	具体价格咨询客服
R36030B-1KG	1 kg

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Details

SiliaBond^® Glycidoxy (Si-GLY) may be used as a linker for further modification of the surface and for the immobilization of molecules bearing amino, hydroxy, mercapto and thiocarboxylic acid groups.

PRODUCT SPECIFICATIONS

MSDS-R36030B

Additional Information

Particle Shape	Irregular
Array	Glycidoxy
Family / Formats	SiliaBond® (Functionalized Silicas)
Particle Size	40 – 63 µm / 230 – 400 mesh
Pore Size	60 Å
Endcapping	Non-endcapped
Storage Condition	Keep dry and cool (<8°C)

抗微管蛋白（甘氨酰化），多克隆抗体（Gly-pep1） anti-Tubulin (glycylated), pAb (Gly-pep1)

发表于2024年3月24日由Whatman官网

抗微管蛋白（甘氨酰化），多克隆抗体（Gly-pep1）
anti-Tubulin (glycylated), pAb (Gly-pep1)

产品特性
相关资料
Q&A
参考文献

抗微管蛋白（甘氨酰化），多克隆抗体（Gly-pep1）

anti-Tubulin (glycylated), pAb (Gly-pep1)

产品编号	产品名称	包装
AG-25B-0034-C100	抗微管蛋白（甘氨酰化），多克隆抗体（Gly-pep1） anti-Tubulin (glycylated), pAb (Gly-pep1)	100 μg

◆产品规格

产品详情
产品类别	多克隆抗体
来源/宿主	兔
免疫原/抗原	对应于人微管蛋白β-2A链的D431EQGEFE（G-COOH）EEEG441-NH2 （从谷氨酸的γ-羧基分支的甘氨酸作为异肽键）的合成肽。
应用	Western Blot: (1：10,000)
	免疫组化: (1：5,000)
	免疫共沉淀: (1：200)
交叉反应	狗
	人
	小鼠
特异性	该抗体识别单糖或双糖化微管蛋白。培养细胞中的甘氨酰酶（TTLL3和TTLL8）的活性主要导致α-和β-微管蛋白的修饰，但也导致其他尚未鉴定的蛋白质底物被抗体Gly-pep1检测到。在免疫荧光标记中，该抗体强烈标记甘氨酰化微管（Gadadhar等，2017）。
纯度	≥95% (SDS-PAGE)
纯化详情	表位亲和纯化
浓度	1 mg/mL
规格	液体。在含有0.02％叠氮化钠的PBS中保存。
Accession Number	Q13885
运输及储存
运输	蓝冰
短期存储	+4°C
长期存储	-20°C
储存建议	重新配制后，建议分装并储存于-20°C。
储存建议	避免反复冻融。
使用/稳定性	收到产品后可在-20℃稳定保存至少6个月。

◆产品描述

　　微管是在所有真核细胞中都能发现的关键细胞骨架元件。一般认为是通过“微管蛋白密码”调控机制来生成不同特性的微管，从而使微管能实现多种不同功能。标记微管的一种机制是通过各种各样的微管蛋白翻译后修饰（PTM）。其中一种修饰方式是甘氨酰化，通过将二级甘氨酸链（支链）添加到蛋白质的主肽链产生。这些支链的长度可以从一个到二十个以上的甘氨酸残基不等。甘氨酰化由来自微管蛋白酪氨酸连接酶样（TTLL）家族的酶TTLL3，TTLL8和TTLL10催化。尤其是TTLL3和TTLL8对于甘氨酰化起始是必需的，因为它们产生初始的甘氨酸链。
　　Gly-pep1抗体是通过模拟β2-微管蛋白（TUBB2A）在E437位点上带有单甘氨酸链的多肽而制备的抗体。本抗体可以特异性地检测甘氨酰化的微管蛋白，以及在细胞以及组织中的其他未知的甘氨酰化底物。因微管的甘氨酰化主要在纤毛和鞭毛中发生，Gly-pep1还可以标记能动的纤毛以及原纤毛（Gadadhar等，2017）。

◆参考文献

Tubulin glycylation controls primary cilia length: S. Gadadhar, et al.; J. Cell Biol. (Article in press) (2017)

◆实验数据

抗微管蛋白（甘氨酰化），多克隆抗体（Gly-pep1） anti-Tubulin (glycylated), pAb (Gly-pep1)

　　使用抗微管蛋白（甘氨酰化），多克隆抗体（Gly-pep1）（产品编号AG-25B-0034）进行蛋白质甘氨酰化的免疫印迹分析。实验方法：在标准条件下培养HEK-293T细胞，转染表达甘氨酰酶TTLL3和TTLL8的质粒，并在10％SDS-PAGE上进行电泳。使用小鼠睾丸的裂解液作为甘氨酰化微管蛋白的阳性对照。将蛋白转至NC膜并进行免疫印迹检测，以抗微管蛋白（甘氨酰化）多克隆抗体（Gly-pep1）（1：20,000）在含0.1％Tween-20的TBS（TBS-T）中进行洗涤，在含2.5％脱脂牛奶的TBS-T中进行抗体孵育。在未转染的HEK-293T细胞提取物中，即使在高度曝光下也检测不到微管蛋白。在TTLL3甘氨酰酶表达后，主要是β-微管蛋白被Gly-pep1检测出来，同时，TTLL8表达产生了Gly-pep1阳性的 α-微管蛋白以及其他尚未鉴定的底物。睾丸裂解液也含有不同甘氨酰化蛋白的异质混合物，包括α和β-微管蛋白。图片由巴黎居里研究所的Sudarshan Gadadhar和Carsten Janke提供。

抗微管蛋白（甘氨酰化），多克隆抗体（Gly-pep1） anti-Tubulin (glycylated), pAb (Gly-pep1)

　　使用抗微管蛋白（甘氨酰化）多克隆抗体（Gly-pep1）（产品编号AG-25B-0034）对多纤毛室管膜细胞和带有初级纤毛的细胞进行免疫荧光染色。实验方法：从新生野生型小鼠分离的放射状神经胶质细胞和血清饥饿诱导MDCK细胞系的纤毛发生。用微管稳定化方法固定细胞并用抗微管蛋白（甘氨酰化）多克隆抗体（Gly-pep1）（1:5,000；红色），抗α-微管蛋白（乙酰化）多克隆抗体（TEU318）（AG-20B -0068）（绿色）和DAPI（蓝色）染色。在纤毛上观察到Gly-pep1特异性染色。图片由巴黎居里研究所的Sudarshan Gadadhar和Carsten Janke提供。

◆相关产品

产品编号	产品名称	包装
AG-20B-0020B-C100	anti-Polyglutamylation Modification, mAb (GT335) (Biotin) 聚麸胺修饰单抗（GT335）（生物素标记）	100 μg
AG-20B-0020-C100	anti-Polyglutamylation Modification, mAb (GT335) 聚麸胺修饰单抗（GT335）	100 μg
AG-27B-0005-C100	anti-alpha-Tubulin, mAb (rec.) (F2C) 重组型alpha微管蛋白单抗（F2C）	100 μg
AG-27B-0005TD-C100	anti-alpha-Tubulin, mAb (rec.) (F2C) (ATTO 488) 重组型alpha微管蛋白单抗（F2C）（ATTO 488）	100 μg
AG-27B-0009-C100	anti-Tubulin-GTP, mAb (rec.) (MB11) 重组型微管蛋白-GTP单抗（MB11）	100 μg
AG-20B-0068-C100	anti-alpha-Tubulin (acetylated), mAb (TEU318) α-微管蛋白（乙酰化）, 单克隆抗体（TEU318）	100 μg
AG-27B-0008-C100	anti-beta-Tubulin, mAb (rec.) (S11B) 重组型beta微管蛋白单抗（S11B）	100 μg

※ 本页面产品仅供研究用，研究以外不可使用。

(Pro-Pro-Gly)10.nH2O （脯氨酸-脯氨酸-甘氨酸）10.n水品牌：Peptide

发表于2024年3月21日由Whatman官网

(Pro-Pro-Gly)10.nH2O

（脯氨酸-脯氨酸-甘氨酸）10.n水

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
331-40061	–	25mg	–	咨询	–	–

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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

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标签归档：gly

Boc-Gly-Gly-Phe-Gly-OH

Z-Gly-Gly-Arg-AMC acetate

Z-Gly-Gly-Arg-AMC acetate 相关产品

bull;相关化合物库:

Arg-Gly-Asp-Ser(Synonyms: RGDS peptide Fibronectin tetrapeptide)

Arg-Gly-Asp-Ser 相关产品

bull;相关化合物库:

Gly-Arg-Gly-Asp-Ser

Gly-Arg-Gly-Asp-Ser 相关产品

bull;相关化合物库:

Tyr-Gly-Gly-Phe-Met-OH(Synonyms: 蛋氨酸脑啡肽 Met-Enkephalin Methionine enkephalin)

Tyr-Gly-Gly-Phe-Met-OH 相关产品

bull;相关化合物库:

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA 相关产品

bull;相关化合物库:

H-Gly-Pro-OH

H-Gly-Pro-OH 相关产品

bull;相关化合物库:

加拿大Silicycle硅胶填料SiliaBond Glycidoxy (GLY) nec (R36030B)

Details

Additional Information

抗微管蛋白（甘氨酰化），多克隆抗体（Gly-pep1） anti-Tubulin (glycylated), pAb (Gly-pep1)

(Pro-Pro-Gly)10.nH2O （脯氨酸-脯氨酸-甘氨酸）10.n水品牌：Peptide

(Pro-Pro-Gly)10.nH2O

（脯氨酸-脯氨酸-甘氨酸）10.n水