标签归档：tyr

Bz-Tyr-OEt 品牌：Peptide

发表于由

Bz-Tyr-OEt

品牌：Peptide
CAS No.：3483-82-7
储存条件：2-10℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

336-30104

 – 5 g –

Bz-Tyr-OEt 品牌：Peptide

 – –


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Fmoc-Tyr(tBu)-Thr(psi(Me,Me)pro)-OH

发表于由

Fmoc-Tyr(tBu)-Thr(psi(Me,Me)pro)-OH;

Fmoc-Tyr(tBu)-Thr(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Tyr(tBu)-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Tyr(tBu)-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 920519-31-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Tyr(tBu)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

600.70

Formula

C35H40N2O7
CAS 号

920519-31-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Tyrosylleucine(Synonyms: Tyr-Leu)

发表于由

Tyrosylleucine;(Synonyms: Tyr-Leu)

Tyrosylleucine (Tyr-Leu, YL) 是具有口服活性的二肽，具有类似抗抑郁活性。

Tyrosylleucineamp;;(Synonyms: Tyr-Leu)

Tyrosylleucine Chemical Structure

CAS No. : 17355-10-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Tyrosylleucine 的其他形式现货产品:

Tyrosylleucine TFA

生物活性

Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

体内研究
(In Vivo)

Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice (24-27 g)[1]
Dosage: 0.1-30 mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100 mg/kg, p.o.
Administration: Administered orally, intracerebroventricularly, or intraperitoneally
Result: Decreased immobility time after intraperitoneal (1-30 mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST.
Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice.

分子量

294.35

Formula

C15H22N2O4
CAS 号

17355-10-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro:;

H2O : 250 mg/mL (849.33 mM; Need ultrasonic)

DMSO : 250 mg/mL (849.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3973 mL 16.9866 mL 33.9732 mL
5 mM 0.6795 mL 3.3973 mL 6.7946 mL
10 mM 0.3397 mL 1.6987 mL 3.3973 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.07 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.07 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.07 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257.

    [2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.

[Tyr11]-Somatostatin

发表于由

[Tyr11]-Somatostatin;

[Tyr11]-Somatostatin 是一种用于蛋白质组学研究的神经活性肽。Somatostatin 是影响视网膜生理的多种神经活性物质之一。

[Tyr11]-Somatostatinamp;;

[Tyr11]-Somatostatin Chemical Structure

CAS No. : 59481-27-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Tyr11]-Somatostatin is a neuroavtive peptide for proteomics research. Somatostatin is one of many neuroactive substances that influence retinal physiology[1].

体外研究
(In Vitro)

Iodination of [Tyr11]-Somatostatin yields a super high affinity ligand for somatostatin receptors in GH4C1 pituitary cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1653.88

Formula

C76H104N18O20S2
CAS 号

59481-27-5
Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Tyr-Thr-Ser-Cys (Disulfide bridge:Cys3-Cys14)
Sequence Shortening

AGCKNFFWKTYTSC (Disulfide bridge:Cys3-Cys14)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Vasilaki A, et al. Somatostatin mediates nitric oxide production by activating sst(2) receptors in the rat retina. Neuropharmacology. 2002;43(5):899-909.

    [2]. Presky DH, Schonbrunn A. Iodination of [Tyr11]somatostatin yields a super high affinity ligand for somatostatin receptors in GH4C1 pituitary cells. Mol Pharmacol. 1988;34(5):651-658.

H-Ala-Ala-Tyr-OH TFA

发表于由

H-Ala-Ala-Tyr-OH TFA;

H-Ala-Ala-Tyr-OH TFA 可用于合成突变型多肽。

H-Ala-Ala-Tyr-OH TFAamp;;

H-Ala-Ala-Tyr-OH TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

H-Ala-Ala-Tyr-OH TFA can be synthesized mutant peptides[1][2].

分子量

437.37

Formula

C17H22F3N3O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. das Neves GM, et al. In Silico Design of New Inhibitors of Guanine Phosphoribosyltransferase (GPRT) from Giardia lamblia as Antiparasitic Drug Candidates. Curr Drug Discov Technol. 2017;14(1):8-24.

    [2]. B-cell antigenic multi-epitope peptide linked in tandem in OmpU of vibrio mimicus, making method and application thereof. CN101747416A.

H-Ala-Ala-Tyr-OH

发表于由

H-Ala-Ala-Tyr-OH;

H-Ala-Ala-Tyr-OH 用于合成突变型多肽。

H-Ala-Ala-Tyr-OHamp;;

H-Ala-Ala-Tyr-OH Chemical Structure

CAS No. : 67131-52-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

H-Ala-Ala-Tyr-OH can be synthesized mutant peptides[1][2].

分子量

323.34

Formula

C15H21N3O5
CAS 号

67131-52-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. das Neves GM, et al. In Silico Design of New Inhibitors of Guanine Phosphoribosyltransferase (GPRT) from Giardia lamblia as Antiparasitic Drug Candidates. Curr Drug Discov Technol. 2017;14(1):8-24.

    [2]. B-cell antigenic multi-epitope peptide linked in tandem in OmpU of vibrio mimicus, making method and application thereof. CN101747416A.

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

发表于由

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH;

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) 是一种高亲和力的五肽，与 src SH2 域结合 (IC50≈1 µM)。Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH 是 src SH3-SH2：磷酸蛋白相互作用的抑制剂。

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OHamp;;

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH Chemical Structure

CAS No. : 159439-02-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].

分子量

803.70

Formula

C32H46N5O17P
CAS 号

159439-02-8
Sequence Shortening

Ac–{Tyr(PO3H2)}-EEIE-OH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41(11):1894-908.

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH

发表于由

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH;

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 878797-09-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

586.67

Formula

C34H38N2O7
CAS 号

878797-09-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyclo(Gly-Tyr)

发表于由

Cyclo(Gly-Tyr);

Cyclo(Gly-Tyr) 是一种环状二肽。

Cyclo(Gly-Tyr)amp;;

Cyclo(Gly-Tyr) Chemical Structure

CAS No. : 5845-66-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Cyclo(Gly-Tyr) is a cyclic dipeptide[1].

分子量

220.22

Formula

C11H12N2O3
CAS 号

5845-66-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Takashi Mizuma, et al. Uptake of Cyclic Dipeptide by PEPT1 in Caco-2 Cells: Phenolic Hydroxyl Group of Substrate Enhances Affinity for PEPT1. J Pharm Pharmacol. 2002 Sep;54(9):1293-6.

[Des-Tyr1]-Met-Enkephalin

发表于由

[Des-Tyr1]-Met-Enkephalin;

[Des-Tyr1]-Met-Enkephalin 是一种四肽，是脑啡肽的降解产物。

[Des-Tyr1]-Met-Enkephalinamp;;

[Des-Tyr1]-Met-Enkephalin Chemical Structure

CAS No. : 61370-88-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

[Des-Tyr1]-Met-Enkephalin, a tetrapeptide, is a degradationproduct of enkephalins[1].

体外研究
(In Vitro)

Tetrapeptide H-gily-gly-phe-met-oh shows very littleactivity using the mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

410.49

Formula

C18H26N4O5S
CAS 号

61370-88-5
Sequence Shortening

GGFM
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. J M Hambrook, et al. Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates. Nature. 1976 Aug 26;262(5571):782-3.