Cyclo(Ala-Glu)

Cyclo(Ala-Glu);

Cyclo(Ala-Glu) 是一种环状二肽。

Cyclo(Ala-Glu)amp;;

Cyclo(Ala-Glu) Chemical Structure

CAS No. : 16364-36-6

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生物活性

Cyclo(Ala-Glu) is a cyclic dipeptide[1].

分子量

200.19

Formula

C8H12N2O4

CAS 号

16364-36-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Takashi Mizuma, et al. Uptake of Cyclic Dipeptide by PEPT1 in Caco-2 Cells: Phenolic Hydroxyl Group of Substrate Enhances Affinity for PEPT1. J Pharm Pharmacol. 2002 Sep;54(9):1293-6.

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA;

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) 是一种高亲和力的五肽,与 src SH2 域结合 (IC50≈1 µM)。Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA 是 src SH3-SH2:磷酸蛋白相互作用的抑制剂。

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFAamp;;

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA Chemical Structure

规格 是否有货
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生物活性

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].

分子量

917.73

Formula

C34H47F3N5O19P

Sequence Shortening

Ac–{Tyr(PO3H2)}-EEIE-OH

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41(11):1894-908.

H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH

H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH;

H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH (EM7) 是间充质干细胞(MSC)特异性肽。

H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OHamp;;

H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH Chemical Structure

CAS No. : 683750-83-6

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生物活性

H-Glu-Pro-Leu-Gln-Leu-Lys-Met-OH (EM7) is a mesenchymal stem cells (MSC)-specific peptide[1].

分子量

858.06

Formula

C38H67N9O11S

CAS 号

683750-83-6

Sequence Shortening

EPLQLKM

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Limin Cao, et al. The interplay of T1- and T2-relaxation on T1-weighted MRI of hMSCs induced by Gd-DOTA-peptides. Biomaterials. 2014 Apr;35(13):4168-74.

Z-Glu-Tyr-OH

Z-Glu-Tyr-OH; 纯度: 99.88%

Z-Glu-Tyr-OH 可用于固相肽的合成。

Z-Glu-Tyr-OHamp;;

Z-Glu-Tyr-OH Chemical Structure

CAS No. : 988-75-0

规格 价格 是否有货 数量
25 mg ¥600 In-stock
50 mg ¥1000 In-stock
100 mg ¥1600 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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Z-Glu-Tyr-OH 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Z-Glu-Tyr-OH can be used for synthesis of peptides on a solid support[1].

分子量

444.43

Formula

C22H24N2O8

CAS 号

988-75-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (225.01 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2501 mL 11.2504 mL 22.5007 mL
5 mM 0.4500 mL 2.2501 mL 4.5001 mL
10 mM 0.2250 mL 1.1250 mL 2.2501 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (5.63 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.63 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.63 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.63 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.63 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.63 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Rose Haddoub, et al. Enzymatic Synthesis of Peptides on a Solid Support. Org Biomol Chem

[Des-His1,Glu9]-Glucagon amide

[Des-His1,Glu9]-Glucagon amide;

[Des-His1,Glu9]-Glucagon amide 是一种有效的胰高血糖素受体的肽拮抗剂,pA2 值为 7.2。 [Des-His1,Glu9]-Glucagon amide 在糖尿病的发病机理研究中有用。

[Des-His1,Glu9]-Glucagon amideamp;;

[Des-His1,Glu9]-Glucagon amide Chemical Structure

CAS No. : 110084-95-2

规格 是否有货
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[Des-His1,Glu9]-Glucagon amide 的其他形式现货产品:

[Des-His1,Glu9]-Glucagon amide TFA

生物活性

[Des-His1,Glu9]-Glucagon amide is a potent and peptide antagonist of the glucagon receptor, with a pA2 of 7.2. [Des-His1,Glu9]-Glucagon amide is potentially useful in the study of the pathogenesis of diabetes[1].

IC50 Target

glucagon receptor[1]

分子量

3358.65

Formula

C148H221N41O47S

CAS 号

110084-95-2

Sequence

Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2

Sequence Shortening

SQGTFTSEYSKYLDSRRAQDFVQWLMNT-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Unson CG, et, al. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides. 1989 Nov; 10(6): 1171-7.

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH;

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH是个二肽。

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 957780-56-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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生物活性

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

566.64

Formula

C31H38N2O8

CAS 号

957780-56-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Ala-Glu-OH

Ala-Glu-OH; 纯度: ge;98.0%

Ala-Glu-OH 是一种二肽试剂。

Ala-Glu-OHamp;;

Ala-Glu-OH Chemical Structure

CAS No. : 13187-90-1

规格 价格 是否有货 数量
10 mg ¥500 In-stock
25 mg ¥900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Ala-Glu-OH 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Ala-Glu-OH is an agent of the dipeptide[1][2].

分子量

218.21

Formula

C8H14N2O5

CAS 号

13187-90-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 250 mg/mL (1145.69 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.5827 mL 22.9137 mL 45.8274 mL
5 mM 0.9165 mL 4.5827 mL 9.1655 mL
10 mM 0.4583 mL 2.2914 mL 4.5827 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Smid EJ, et al. Mechanism and energetics of dipeptide transport in membrane vesicles of Lactococcus lactis. J Bacteriol. 1989;171(1):292-298.

    [2]. Kim SJ, et al. Replacement of glutamine with the dipeptide derivative alanyl-glutamine enhances in vitro maturation of porcine oocytes and development of embryos. Zygote. 2014;22(2):286-289.

Ac-Ile-Glu-Thr-Asp-pNA

Ac-Ile-Glu-Thr-Asp-pNA;

Ac-Ile-Glu-Thr-Asp-pNA 是 caspase-8 的底物。Caspase-8 结合并裂解Ile-Glu-Thr-Asp (IETD) 肽序列,释放对硝基苯胺,可通过 405 nm 处的比色检测来定量检测酶活性。

Ac-Ile-Glu-Thr-Asp-pNAamp;;

Ac-Ile-Glu-Thr-Asp-pNA Chemical Structure

CAS No. : 219138-21-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1].

分子量

638.62

Formula

C27H38N6O12

CAS 号

219138-21-3

Sequence Shortening

Ac-IETD-pNA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Smith GK, et al. Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition. Arch Biochem Biophys. 2002;399(2):195-205.

[Glu4]-Oxytocin

[Glu4]-Oxytocin;

[Glu4]-Oxytocin 是一种催产素衍生物,可通过多种方法对水溶液中的 “类催产素” 分子的构象进行综合研究。

[Glu4]-Oxytocinamp;;

[Glu4]-Oxytocin Chemical Structure

CAS No. : 4314-67-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Glu4]-Oxytocin is an appropriate derivative of oxytocin for conducting a comprehensive investigation by a variety of methods of the conformation of “oxytocin-like” molecules in aqueous solution[1].

分子量

1008.17

Formula

C43H65N11O13S2

CAS 号

4314-67-4

Sequence Shortening

CYIENCPLG-NH2 (Disulfide bridge:Cys1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Walter R, et al. H N.M.R. study of the conformation of [Glu4] oxytocin and its lanthanide complexes in aqueous solution. Int J Pept Protein Res. 1981;17(1):56-64.

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH;

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) 是一种高亲和力的五肽,与 src SH2 域结合 (IC50≈1 µM)。Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH 是 src SH3-SH2:磷酸蛋白相互作用的抑制剂。

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OHamp;;

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH Chemical Structure

CAS No. : 159439-02-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].

分子量

803.70

Formula

C32H46N5O17P

CAS 号

159439-02-8

Sequence Shortening

Ac–{Tyr(PO3H2)}-EEIE-OH

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41(11):1894-908.