γ-Glu-Phe(Synonyms: γ-Glutamylphenylalanine)

γ-Glu-Phe;(Synonyms: γ-Glutamylphenylalanine) 纯度: 99.85%

γ-Glu-Phe (γ-Glutamylphenylalanine) 是由解淀粉芽孢杆菌 (GBA) 和米曲霉 (GAO) 合成的。γ-Glu-Phe 或酶后反应混合物可增强商业酱油和模型鸡汤的鲜味强度。

γ-Glu-Pheamp;;(Synonyms: γ-Glutamylphenylalanine)

γ-Glu-Phe Chemical Structure

CAS No. : 7432-24-8

规格 价格 是否有货 数量
5 mg ¥700 In-stock
10 mg ¥1100 In-stock
50 mg ¥2400 In-stock
100 mg ¥3500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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gamma;-Glu-Phe 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Human Endogenous Metabolite Compound Library
  • Peptidomimetic Library
  • Microbial Metabolite Library
  • Food-Sourced Compound Library
  • Peptide Library

生物活性

γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth[1].

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

γ-Glu-Phe, γ-Glu-Met and γ-Glu-Val, are identified in sourdough by liquid chromatography-tandem mass spectrometry in MRM mode. γ-Glutamyl dipeptides are found in higher concentrations in sourdough fermented with L. reuteri when compared to the chemically acidified controls. Proteolysis is an important factor for generation of γ-glutamyl dipeptides. Sensory evaluation of bread reveals that sourdough bread with higher concentrations of γ-glutamyl dipeptides ranks higher with respect to the taste intensity when compared to regular bread and type I sourdough bread. Sourdough breads fermented with L. reuteri LTH5448 and L. reuteri 100-23 differ with respect to the intensity of the salty taste; this difference corresponds to a different concentration of γ-glutamyl dipeptides[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

294.30

Formula

C14H18N2O5

CAS 号

7432-24-8

Sequence

gamma;-Glu-Phe

Sequence Shortening

gamma;-EF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 50 mg/mL (169.89 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3979 mL 16.9895 mL 33.9789 mL
5 mM 0.6796 mL 3.3979 mL 6.7958 mL
10 mM 0.3398 mL 1.6989 mL 3.3979 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Yang J, et al. Synthesis and Sensory Characteristics of Kokumi γ-[Glu]n-Phe in the Presence of Glutamine and Phenylalanine: Glutaminase from Bacillus amyloliquefaciens or Aspergillus oryzae as the Catalyst. J Agric Food Chem. 2017 Oct 4;65(39):8696-8703.

    [2]. Zhao CJ, et al. Synthesis of Taste-Active γ-Glutamyl Dipeptides during Sourdough Fermentation by Lactobacillus reuteri. J Agric Food Chem. 2016 Oct 12;64(40):7561-7568.

Oglufanide(Synonyms: 奥谷法奈 H-Glu-Trp-OH L-Glutamyl-L-tryptophan)

Oglufanide;(Synonyms: 奥谷法奈; H-Glu-Trp-OH; L-Glutamyl-L-tryptophan) 纯度: 99.49%

Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来二肽免疫调节剂,可抑制血管内皮生长因子(VEGF)。Oglufanide 可以刺激对丙型肝炎病毒 (HCV) 和细胞内细菌感染的免疫反应。

Oglufanideamp;;(Synonyms: 奥谷法奈; H-Glu-Trp-OH;  L-Glutamyl-L-tryptophan)

Oglufanide Chemical Structure

CAS No. : 38101-59-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ¥1430 In-stock
5 mg ¥1300 In-stock
10 mg ¥2100 In-stock
25 mg ¥4200 In-stock
50 mg ¥6700 In-stock
100 mg ¥9800 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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Oglufanide 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Immunology/Inflammation Compound Library
  • Kinase Inhibitor Library
  • Metabolism/Protease Compound Library
  • Protein Tyrosine Kinase Compound Library
  • Natural Product Library
  • Clinical Compound Library
  • Antiviral Compound Library
  • Human Endogenous Metabolite Compound Library
  • Peptidomimetic Library
  • Drug Repurposing Compound Library
  • Differentiation Inducing Compound Library
  • Reprogramming Compound Library
  • Anti-Cardiovascular Disease Compound Library
  • Anti-COVID-19 Compound Library
  • Anti-Hepatitis C Virus Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Lung Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Angiogenesis Related Compound Library
  • Anti-Liver Cancer Compound Library
  • Rare Diseases Drug Library
  • Anti-Colorectal Cancer Compound Library
  • Peptide Library

生物活性

Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections[1][2].

IC50 Target

Human Endogenous Metabolite

;

Clinical Trial

分子量

333.34

Formula

C16H19N3O5

CAS 号

38101-59-6

中文名称

奥谷法奈;L-谷氨酰-L-色氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 15.5 mg/mL (46.50 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9999 mL 14.9997 mL 29.9994 mL
5 mM 0.6000 mL 2.9999 mL 5.9999 mL
10 mM 0.3000 mL 1.5000 mL 2.9999 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.50 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.50 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.50 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Bayes M, et al. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27(6):411-61.

    [2]. Nagendra Kumar Kaushik, et al. Biomedical importance of indoles. Molecules. 2013 Jun 6;18(6):6620-62.

[Des-His1,Glu9]-Glucagon amide TFA

[Des-His1,Glu9]-Glucagon amide TFA; 纯度: 98.29%

[Des-His1,Glu9]-Glucagon amide TFA 是一种有效的胰高血糖素受体的肽拮抗剂,pA2 值为 7.2。 [Des-His1,Glu9]-Glucagon amide TFA 在糖尿病的发病机理研究中有用。

[Des-His1,Glu9]-Glucagon amide TFAamp;;

[Des-His1,Glu9]-Glucagon amide TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥2800 In-stock
5 mg ¥8500 In-stock
10 mg ¥13500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

[Des-His1,Glu9]-Glucagon amide TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

[Des-His1,Glu9]-Glucagon amide TFA is a potent and peptide antagonist of the glucagon receptor, with a pA2 of 7.2. [Des-His1,Glu9]-Glucagon amide TFA is potentially useful in the study of the pathogenesis of diabetes[1].

IC50 Target

glucagon receptor[1]

分子量

3472.67

Formula

C150H222F3N41O49S

Sequence

Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2

Sequence Shortening

SQGTFTSEYSKYLDSRRAQDFVQWLMNT-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Unson CG, et, al. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides. 1989 Nov; 10(6): 1171-7.

人iPS细胞来源的谷氨酸能神经元祖细胞 ReproNeuro Glu™ kit

人iPS细胞来源的谷氨酸能神经元祖细胞
ReproNeuro Glu™ kit

  • 产品特性
  • 相关资料
  • Q&A
  • 参考文献

人iPS细胞来源的谷氨酸能神经元祖细胞人iPS细胞来源的谷氨酸能神经元祖细胞                              ReproNeuro Glu™ kit

ReproNeuro Glu ™ kit


人iPS细胞来源的谷氨酸能神经元祖细胞                              ReproNeuro Glu™ kit


ReproNeuro Glu & Alzheimer’sDisease Model Cells 人iPS 细胞诱导的神经细胞,用于阿尔茨海默病的研究。

◆特点•优势


 世界首例来源于人iPS 细胞的谷氨酸(Glu) 神经细胞和AD 模型神经细胞

● 实验成像图显示体外培养神经细胞与典型 AD 患者的表型相同(β 淀粉样蛋白聚集)

● 适用于高通量筛选


◆案例•应用

可根据实验需要选择以下三种产品


人iPS细胞来源的谷氨酸能神经元祖细胞                              ReproNeuro Glu™ kit



 高纯度(>80%)谷氨酸神经细胞

人iPS细胞来源的谷氨酸能神经元祖细胞                              ReproNeuro Glu™ kit

Note) Blue:DAPI

阿尔茨海默病(AD)的体外检测

                           

Aβ 聚集


 体外AD 表型和药物作用的检测。


人iPS细胞来源的谷氨酸能神经元祖细胞                              ReproNeuro Glu™ kit

人iPS细胞来源的谷氨酸能神经元祖细胞                              ReproNeuro Glu™ kit


产品信息


产品编号

产品名称

产品描述

RCESDG002

ReproNeuro Glu™ kit

iPS细胞来源的谷氨酸能神经元祖细胞

Glutamatergic neurons derived from a human cell line without gene manipulatiuon.3×105 cells+reagents

RCESDG104

ReproNeuro Glu-AD™ (PS1 wild type)

iPS细胞来源的谷氨酸能神经元祖细胞(preseninlin-1的野生型拷贝)

Glutamatergic neurons derived from a human iPS cell line with a wild type copy ofPresenilin-1. 3×105cells+reagents

RCESDG106

ReproNeuro Glu-AD™ (PS1 P117L

iPS细胞来源的谷氨酸能神经元祖细胞(preseninlin-1的突变体(P117L)拷贝)

Glutamatergic neurons derived from a human iPS cell line with a mutant   (P117L) copy of Presenilin-1added. 3×105 cells+reagents

Refill Reagents for ReproNeuro Glu™

Glu Matuation Medium™ , Glu Additive™ , Glu   Thawing Medium™ , Glu Coat™

ReproUNUS™

Service to establish customised transgenic/patient-derived model neurons

※ 本页面产品仅供研究用,研究以外不可使用。

产品列表
产品编号 产品名称 产品规格 产品等级 备注
RCESDG002 ReproNeuro Glu™ kit
人iPS细胞来源的谷氨酸能神经元祖细胞
1 Kit
RCESDG104 ReproNeuro Glu-AD™ (PS1 wild type)
 人iPS细胞来源的谷氨酸能神经元祖细胞(preseninlin-1的野生型拷贝)
RCESDG106 ReproNeuro Glu-AD™ (PS1 P117L
 人iPS细胞来源的谷氨酸能神经元祖细胞(preseninlin-1的突变体(P117L)拷贝)

Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2; 纯度: 98.04%

Fmoc-Ala-Glu-Asn-Lys-NH2 是一种选择性天冬酰胺内肽酶 AEP 抑制肽,可抑制淀粉样前体蛋白 APP 裂解。AEP是一种 pH 值控制的半胱氨酸蛋白酶,在衰老过程中被激活并介导 APP 蛋白水解过程。

Fmoc-Ala-Glu-Asn-Lys-NH2amp;;

Fmoc-Ala-Glu-Asn-Lys-NH2 Chemical Structure

CAS No. : 220701-06-4

规格 价格 是否有货 数量
5 mg ¥1350 In-stock
10 mg ¥2350 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Fmoc-Ala-Glu-Asn-Lys-NH2 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Neuronal Signaling Compound Library
  • Anti-Alzheimer’s Disease Compound Library
  • Peptide Library

生物活性

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

体外研究
(In Vitro)

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

681.74

Formula

C33H43N7O9

CAS 号

220701-06-4

Sequence Shortening

{Fmoc}-AENK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4668 mL 7.3342 mL 14.6683 mL
5 mM 0.2934 mL 1.4668 mL 2.9337 mL
10 mM 0.1467 mL 0.7334 mL 1.4668 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.

Ac-Asp-Glu . H2O 品牌:Peptide


Ac-Asp-Glu . H2O

品牌:Peptide
CAS No.:3106-85-2
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

334-41673

25mg 咨询


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Z-Leu-Leu-Glu-AMC 品牌:Enzo


Z-Leu-Leu-Glu-AMC

品牌:Enzo
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

BML-ZW9345-0050

50 mg 23,700.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Glu(pNA) H2O 品牌:Peptide


Glu(pNA) H2O

品牌:Peptide
CAS No.:
储存条件:2-10℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

338-30664

5g 咨询


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Boc-Ile-Glu-Gly-Arg-MCA 品牌:Peptide


Boc-Ile-Glu-Gly-Arg-MCA

品牌:Peptide
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

338-30941

5mg 咨询


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Boc-Glu-Lys-Lys-MCA 品牌:Peptide


Boc-Glu-Lys-Lys-MCA

品牌:Peptide
CAS No.:73554-85-5
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

335-31051

5mg 咨询


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。