Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OH

Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OH;

Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 1000164-43-1

规格 是否有货
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250 mg ; 询价 ;
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生物活性

Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

510.58

Formula

C28H34N2O7

CAS 号

1000164-43-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH;

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Leu-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 955048-89-2

规格 是否有货
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生物活性

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

494.58

Formula

C28H34N2O6

CAS 号

955048-89-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH;

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Phe-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 1196703-48-6

规格 是否有货
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250 mg ; 询价 ;
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生物活性

Fmoc-Phe-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

528.60

Formula

C31H32N2O6

CAS 号

1196703-48-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH;

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 878797-09-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

586.67

Formula

C34H38N2O7

CAS 号

878797-09-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH

Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH;

Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 1572725-72-4

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

751.87

Formula

C46H45N3O7

CAS 号

1572725-72-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH;

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Leu-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 339531-50-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

480.55

Formula

C27H32N2O6

CAS 号

339531-50-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Fmoc-Glu(OtBu)-Ser(psi(Me,Me)pro)-OH

Fmoc-Glu(OtBu)-Ser(psi(Me,Me)pro)-OH;

Fmoc-Glu(OtBu)-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Glu(OtBu)-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Glu(OtBu)-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 909115-33-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Glu(OtBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

552.62

Formula

C30H36N2O8

CAS 号

909115-33-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Ermelinda Vernieri, et al. An optimized Fmoc synthesis of human defensin 5. Amino Acids. 2014 Feb;46(2):395-400.

Fmoc-Ala-Thr(psi(Me,Me)pro)-OH

Fmoc-Ala-Thr(psi(Me,Me)pro)-OH;

Fmoc-Ala-Thr(psi(Me,Me))-OH 是 Fmoc 保护的丙氨酸衍生物,可用于肽合成。

Fmoc-Ala-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Ala-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 252554-79-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Ala-Thr(psi(Me,Me))-OH is an Fmoc protected alanine derivative and can be used for peptide synthesis.

分子量

452.50

Formula

C25H28N2O6

CAS 号

252554-79-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Fmoc-Ala-Ser(psi(Me,Me)pro)-OH

Fmoc-Ala-Ser(psi(Me,Me)pro)-OH;

Fmoc-Ala-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Ala-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Ala-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 252554-78-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Ala-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

438.47

Formula

C24H26N2O6

CAS 号

252554-78-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2; 纯度: 98.04%

Fmoc-Ala-Glu-Asn-Lys-NH2 是一种选择性天冬酰胺内肽酶 AEP 抑制肽,可抑制淀粉样前体蛋白 APP 裂解。AEP是一种 pH 值控制的半胱氨酸蛋白酶,在衰老过程中被激活并介导 APP 蛋白水解过程。

Fmoc-Ala-Glu-Asn-Lys-NH2amp;;

Fmoc-Ala-Glu-Asn-Lys-NH2 Chemical Structure

CAS No. : 220701-06-4

规格 价格 是否有货 数量
5 mg ¥1350 In-stock
10 mg ¥2350 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Fmoc-Ala-Glu-Asn-Lys-NH2 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Neuronal Signaling Compound Library
  • Anti-Alzheimer’s Disease Compound Library
  • Peptide Library

生物活性

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

体外研究
(In Vitro)

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

681.74

Formula

C33H43N7O9

CAS 号

220701-06-4

Sequence Shortening

{Fmoc}-AENK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4668 mL 7.3342 mL 14.6683 mL
5 mM 0.2934 mL 1.4668 mL 2.9337 mL
10 mM 0.1467 mL 0.7334 mL 1.4668 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.