标签归档：fmoc

Fmoc-Ala-Glu-Asn-Lys-NH2

发表于由

Fmoc-Ala-Glu-Asn-Lys-NH2; 纯度: 98.04%

Fmoc-Ala-Glu-Asn-Lys-NH2 是一种选择性天冬酰胺内肽酶 AEP 抑制肽，可抑制淀粉样前体蛋白 APP 裂解。AEP是一种 pH 值控制的半胱氨酸蛋白酶，在衰老过程中被激活并介导 APP 蛋白水解过程。

Fmoc-Ala-Glu-Asn-Lys-NH2amp;;

Fmoc-Ala-Glu-Asn-Lys-NH2 Chemical Structure

CAS No. : 220701-06-4

规格 价格 是否有货 数量
5 mg ￥1350 In-stock
10 mg ￥2350 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Fmoc-Ala-Glu-Asn-Lys-NH2 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Neuronal Signaling Compound Library
  • Anti-Alzheimer’s Disease Compound Library
  • Peptide Library

生物活性

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

体外研究
(In Vitro)

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

681.74

Formula

C33H43N7O9
CAS 号

220701-06-4
Sequence Shortening

{Fmoc}-AENK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4668 mL 7.3342 mL 14.6683 mL
5 mM 0.2934 mL 1.4668 mL 2.9337 mL
10 mM 0.1467 mL 0.7334 mL 1.4668 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH(Synonyms: Fmoc-Thr(Ac₃AcNH-α-Gal)-OH)

发表于由

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH;(Synonyms: Fmoc-Thr(Ac₃AcNH-α-Gal)-OH) 纯度: 98.36%

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是用于研究制备癌症疫苗的结构单元。

Fmoc-Thr[GalNAc(Ac)3-α-D]-OHamp;;(Synonyms: Fmoc-Thr(Ac₃AcNH-α-Gal)-OH)

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Chemical Structure

CAS No. : 116783-35-8

规格 价格 是否有货 数量
25 mg ￥2950 In-stock
50 mg ￥5200 In-stock
100 mg ￥8100 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Fmoc-Thr[GalNAc(Ac)3-alpha;-D]-OH 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptidomimetic Library
  • Peptide Library

生物活性

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

体外研究
(In Vitro)

The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

670.66

Formula

C33H38N2O13
CAS 号

116783-35-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Ju T, et al. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 1;14(1):63-81.

Fmoc-Asn[per-O-Boc-(Fucα1-6GlcNAcβ)] 品牌：Peptide

发表于由

Fmoc-Asn[per-O-Boc-(Fucα1-6GlcNAcβ)]

品牌：Peptide
CAS No.：
储存条件：-20°C
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

338-00891

 – 10mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH

发表于由

Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH;

Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 1821378-64-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

737.84

Formula

C45H43N3O7
CAS 号

1821378-64-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Fmoc-Ile-Ser(psi(Me,Me)pro)-OH

发表于由

Fmoc-Ile-Ser(psi(Me,Me)pro)-OH;

Fmoc-Ile-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Ile-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Ile-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 1147996-34-6

规格 价格 是否有货 数量
1 g ￥500 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

* Please select Quantity before adding items.

生物活性

Fmoc-Ile-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

480.55

Formula

C27H32N2O6
CAS 号

1147996-34-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Fmoc-Val-Ser(psi(Me,Me)pro)-OH

发表于由

Fmoc-Val-Ser(psi(Me,Me)pro)-OH;

Fmoc-Val-Ser(psi(Me,Me)pro)-OH是一种二肽。

Fmoc-Val-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Val-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 186023-49-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Fmoc-Val-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

466.53

Formula

C26H30N2O6
CAS 号

186023-49-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH

发表于由

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH;

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 936707-21-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

667.75

Formula

C38H41N3O8
CAS 号

936707-21-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Fmoc-Ile-Thr(psi(Me,Me)pro)-OH

发表于由

Fmoc-Ile-Thr(psi(Me,Me)pro)-OH;

Fmoc-Ile-Thr(psi(Me,Me)pro)-OH 是个二肽。

Fmoc-Ile-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Ile-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 957780-52-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Fmoc-Ile-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

494.58

Formula

C28H34N2O6
CAS 号

957780-52-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH

发表于由

Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH;

Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 920519-33-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

723.81

Formula

C44H41N3O7
CAS 号

920519-33-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Fmoc-Gly-Thr(psi(Me,Me)pro)-OH

发表于由

Fmoc-Gly-Thr(psi(Me,Me)pro)-OH; 纯度: 99.30%

Fmoc-Gly-Thr(psi(Me,Me)pro)-OH 是一个二肽。

Fmoc-Gly-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Gly-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 1262308-49-5

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
100 mg ￥500 In-stock
500 mg ￥1200 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

* Please select Quantity before adding items.

Fmoc-Gly-Thr(psi(Me,Me)pro)-OH 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Fmoc-Gly-Thr(psi(Me,Me)pro)-OH is a dipeptide[1].

分子量

438.47

Formula

C24H26N2O6
CAS 号

1262308-49-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 250 mg/mL (570.16 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2807 mL 11.4033 mL 22.8066 mL
5 mM 0.4561 mL 2.2807 mL 4.5613 mL
10 mM 0.2281 mL 1.1403 mL 2.2807 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (4.74 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.74 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.74 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.74 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.74 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.74 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Yuankun Dao, et al. α-Selective Lysine Ligation and Application in Chemical Synthesis of Interferon Gamma. Org Lett. 2019 May 3;21(9):3265-3270.