[1]. Jun Chang, et al.Phenolic glycosides and ionone glycoside from the stem of Sargentodoxa cuneata,Phytochemistry,Phytochemistry. 2005 Dec;66(23):2752-8.
Niga-ichigoside F1 是一种具有口服活性熊果三萜，具有抗高血脂和抗氧化活性。Niga-ichigoside F1 可以预防高脂肪饮食 (HFD) 诱导的肝脂肪变性。
Niga-ichigoside F1 Chemical Structure
CAS No. : 95262-48-9
规格
价格
是否有货
数量
5 mg
￥5200
In-stock
10 mg
￥8400
In-stock
50 mg
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100 mg
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Niga-ichigoside F1 相关产品
bull;相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Natural Product Library
Glycoside Compound Library
Anti-Cardiovascular Disease Compound Library
Terpenoids Library
Orally Active Compound Library
Traditional Chinese Medicine Monomer Library
生物活性
Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis[1].
体外研究 (In Vitro)
Niga-ichigoside F1 (2.5, 5, 10, 20 μM; for 24 hours) inhibits lipid accumu-lation in free fatty acid (FFA)-treated HepG2 cells in a dose-dependent manner. Niga-ichigoside F1 has no effects on cell viability[1]. Both nuclear and cytoplasmic Nrf2 expressions are lowered in Con, Niga-ichigoside F1 (20 μM), FFA (1 mM), and Niga-ichigoside F1 plus FFA treated Nrf2-silenced cells[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Niga-ichigoside F1 (40 mg/kg; oral gavage; for 12 weeks) alleviates hepatic steatosis, possibly by significantly interacting with high-fat diet (HFD) to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5) in four-week-old male C57BL/6J mice[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
666.84
Formula
C36H58O11
CAS 号
95262-48-9
中文名称
苦莓苷F1
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Shu-Fang Xia, et al. Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. Food Funct. 2018 Feb 21;9(2):906-916.
