标签归档：methyl

Methyl-β-cyclodextrin(Synonyms: 甲基-β-环糊精; Methyl-beta-cyclodextrin)

发表于由

生化分析试剂 Biochemical Assay Reagents
Methyl-β-cyclodextrin;(Synonyms: 甲基-β-环糊精; Methyl-beta-cyclodextrin) 纯度: 99.91%

Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) 是一种环庚糖，对非极性物质有增溶作用，广泛应用于疏水性药物的释放。Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) 也广泛用作降胆固醇剂。Methyl-β-cyclodextrin 可显著降低网格蛋白依赖性内吞作用。

Methyl-β-cyclodextrin(Synonyms: 甲基-β-环糊精; Methyl-beta-cyclodextrin)

Methyl-β-cyclodextrin Chemical Structure

CAS No. : 128446-36-6

规格 价格 是否有货 数量
500 mg ￥400 In-stock
1 g ￥500 In-stock
5 g ￥700 In-stock
10 g ￥1000 In-stock
25 g ￥1900 In-stock
50 g ￥2400 In-stock
> 100 g ; 询价 ;

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生物活性

Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic drugs based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent[1]. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis[2].

体外研究
(In Vitro)

Methyl-β-cyclodextrin is extensively used to increase the permeability of cells, and thereby increase the uptake of small molecules such as glucose and nano-particles[3].
Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrins molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs[3].
Methyl-β-cyclodextrin quickly induces caspase-dependent apoptosis in PEL cells via cholesterol depletion from the plasma membrane. Methyl-β-cyclodextrin inhibits the growth of all PEL cell lines in a dose-dependent manner. The IC50 is 3.33-4.23 mM in each cell line[4].
Methyl-β-cyclodextrin is a highly water soluble cyclic heptasaccharide consisting of a β-glucopyranose unit, has been reported as the most effective agent for the depletion of cholesterol from cells among the various cholesterol-depleting agents[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In a PEL xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice[3].
Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. Currently, there are approximately 30 different pharmaceutical products worldwide containing drug/cyclodextrins complexes in the market[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1310 (Average)

CAS 号

128446-36-6
中文名称

甲基-β-环糊精
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
溶解性数据
In Vitro:;

DMSO : ≥ 100 mg/mL

H2O : ≥ 50 mg/mL

* “≥” means soluble, but saturation unknown.
参考文献

  • [1]. Mundhara N, et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638.

    [2]. Rodal SK, et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999;10(4):961-974.

    [3]. Chen X, et al. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20;277(51):49631-7.

    [4]. Gotoh K, et al. The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):285-9.

    [5]. Tiwari G, et al. Cyclodextrins in delivery systems: Applications. J Pharm Bioallied Sci. 2010 Apr;2(2):72-9.
Cell Assay
[1]

PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice: Female NRJ mice are intraperitoneally inoculated with BCBL-1 cells suspended in PBS. The mice are then treated with intraperitoneal injections of PBS or methyl-β-cyclodextrin (500 mg/kg per day). Tumor burdens are evaluated by measuring body weights and ascites[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Mundhara N, et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638.

    [2]. Rodal SK, et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999;10(4):961-974.

    [3]. Chen X, et al. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20;277(51):49631-7.

    [4]. Gotoh K, et al. The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):285-9.

    [5]. Tiwari G, et al. Cyclodextrins in delivery systems: Applications. J Pharm Bioallied Sci. 2010 Apr;2(2):72-9.

Artemether(Synonyms: 蒿甲醚; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Artemether (Synonyms: 蒿甲醚; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224) 纯度: ≥98.0%

Artemether是抗疟疾化合物，可作用于恶性疟疾的耐药株。

Artemether(Synonyms: 蒿甲醚; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224)

Artemether Chemical Structure

CAS No. : 71963-77-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
500 mg ￥990 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Artemether 相关产品

•相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • FDA-Approved Drug Library
  • Anti-Cancer Compound Library
  • Drug Repurposing Compound Library
  • Covalent Screening Library
  • NMPA-Approved Drug Library
  • Terpenoids Library
  • Orally Active Compound Library
  • Traditional Chinese Medicine Monomer Library
  • FDA Approved & Pharmacopeial Drug Library
  • Antiparasitic Compound library
  • Children’s Drug Library

生物活性

Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria. Target: Antiparasitic Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. Artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. Artemether-integrated with other control strategies-has considerable potential for reducing the current burden of schistosomiasis in different epidemiological settings [1]. There were remarkably inhibitory effects of artmeter on brain glioma growth and angiogenesis in SD rats and the mechanism that artemether inhibited brain glioma growth might be penetrating the blood-brain barrier and inhibiting angiogenesis [2].

Clinical Trial

分子量

298.37

Formula

C16H26O5
CAS 号

71963-77-4
中文名称

蒿甲醚；青蒿醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (335.15 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3515 mL 16.7577 mL 33.5154 mL
5 mM 0.6703 mL 3.3515 mL 6.7031 mL
10 mM 0.3352 mL 1.6758 mL 3.3515 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.38 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.38 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.38 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Xiao, S., et al., Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop, 2002. 82(2): p. 175-81.

    [2]. Wu, Z.P., et al., Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model. Integr Cancer Ther, 2009. 8(1): p. 88-92.

Lawsone methyl ether(Synonyms: 2-​Methoxy-​1,​4-​naphthoquinone)

发表于由

天然产物醌类Quinones

Lawsone methyl ether (Synonyms: 2-​Methoxy-​1,​4-​naphthoquinone) 纯度: 98.95%

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和 Swertia calycina 中分离出的，具有有效的抗真菌和抗菌活性。

Lawsone methyl ether(Synonyms: 2-​Methoxy-​1,​4-​naphthoquinone)

Lawsone methyl ether Chemical Structure

CAS No. : 2348-82-5

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
25 mg ￥500 In-stock
50 mg ￥800 In-stock
100 mg ￥1200 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Lawsone methyl ether 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Antifungal Compound Library
  • Antibacterial Compound Library
  • Traditional Chinese Medicine Monomer Library

生物活性

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities[1].

体外研究
(In Vitro)

The value of both minimal inhibitory concentration and minimal fungicidal concentration of Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) against Candida was 1.25 lg⁄ml[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

188.18

Formula

C11H8O3
CAS 号

2348-82-5
中文名称

二氯甲基甲醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (265.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.3141 mL 26.5703 mL 53.1406 mL
5 mM 1.0628 mL 5.3141 mL 10.6281 mL
10 mM 0.5314 mL 2.6570 mL 5.3141 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Sritrairat N, et al. Antifungal activity of lawsone methyl ether in comparison with chlorhexidine. J Oral Pathol Med. 2011 Jan;40(1):90-6.

Methyl cellulose(Synonyms: 甲基纤维素)

发表于由

生化分析试剂 Biochemical Assay Reagents
Methyl cellulose;(Synonyms: 甲基纤维素)

Methyl cellulose 是一种非离子纤维素醚，具有独特的热胶凝性质，没有毒性。

Methyl cellulose(Synonyms: 甲基纤维素)

Methyl cellulose Chemical Structure

CAS No. : 9004-67-5

规格 价格 是否有货 数量
500 mg ￥500 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

* Please select Quantity before adding items.

生物活性

Methylcellulose is a natural polymer which gels on heating. Methylcellulose is not toxic.

体内研究
(In Vivo)

Protocal for preparing 0.5% Methylcellulose Solution
Measure 0.5g of dry Methylcellulose and dissolved in 100 ml ddH2O/0.9% Saline (0.9 g NaCl in 100 ml ddH2O) to make a clear solution.
Under the condition of stirring and heating (50-65°C), adding Methylcellulose slowly to ddH2O/0.9% Saline helps to accelerate dissolution.

Note
1.You must ensure that your Methylcellulose solution does not exist solid-liquid separation phenomenon. The solution is in a uniform and transparent state has no particles in it.
2.Completely dissolution of Methylcellulose may requires 4 hours or more longer.
0.5% Methylcellulose solution (0.5% MC) can be used for oral adminstration or intraperitoneal injection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

CAS 号

9004-67-5
中文名称

甲基纤维素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
溶解性数据
In Vitro:;

H2O : 1 mg/mL (Need ultrasonic)
参考文献

  • [1]. Stacey Meeker, et al. Repeated Intraperitoneal Administration of Low-Concentration Methylcellulose Leads to Systemic Histologic Lesions Without Loss of Preclinical Phenotype. J Pharmacol Exp Ther. 2019 Oct;371(1):25-35

Shanzhiside methyl ester(Synonyms: 山芝皂苷甲酯)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Shanzhiside methyl ester (Synonyms: 山芝皂苷甲酯) 纯度: 98.57%

Shanzhiside methyl ester 是从轮状乳杆菌中分离得到的。Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 (GLP-1 receptor) 受体激动剂，具有诱导抗异常性痛觉耐受的能力。

Shanzhiside methyl ester(Synonyms: 山芝皂苷甲酯)

Shanzhiside methyl ester Chemical Structure

CAS No. : 64421-28-9

规格 价格 是否有货 数量
5 mg ￥800 In-stock
10 mg ￥1400 In-stock
20 mg ￥2300 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Shanzhiside methyl ester 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Natural Product Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Microbial Metabolite Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Anti-Obesity Compound Library

生物活性

Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].

IC50 & Target

IC50: GLP-1 receptor[1]
体内研究
(In Vivo)

Shanzhiside methyl ester exerts dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

406.38

Formula

C17H26O11
CAS 号

64421-28-9
中文名称

山芝皂苷甲酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (246.08 mM; Need ultrasonic)

H2O : 50 mg/mL (123.04 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4608 mL 12.3038 mL 24.6075 mL
5 mM 0.4922 mL 2.4608 mL 4.9215 mL
10 mM 0.2461 mL 1.2304 mL 2.4608 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.15 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.15 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.15 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Fan H, et al. Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.Neuropharmacology. 2016 Feb;101:98-109.

荧光染料7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester

发表于由

荧光染料Dye Reagents 7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester;

7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester 是一种荧光生物试剂，可用于胺反应性标记。

7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester

7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester Chemical Structure

CAS No. : 113721-87-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester is a bioReagent, suitable for fluorescence, can be used for amine-reactive labeling.

分子量

330.29

Formula

C16H14N2O6
CAS 号

113721-87-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

8-Methyl Chrysophanol(Synonyms: Chrysophanol 8-methyl ether)

发表于由

天然产物醌类Quinones

8-Methyl Chrysophanol (Synonyms: Chrysophanol 8-methyl ether)

8-Methyl Chrysophanol 是从Senna macranth 树皮中分离得到的一种蒽醌。

8-Methyl Chrysophanol(Synonyms: Chrysophanol 8-methyl ether)

8-Methyl Chrysophanol Chemical Structure

CAS No. : 3300-25-2

规格 价格 是否有货
1 mg ￥1300 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

8-Methyl Chrysophanol is an anthraquinone isolated from the bark of Senna macranth[1].

分子量

268.26

Formula

C16H12O4
CAS 号

3300-25-2
中文名称

8-甲基大黄酚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Alexsandro Branco, et al. Anthraquinones from the bark of Senna macranthera. An Acad Bras Cienc. 2011 Dec;83(4):1159-64.

Rubiadin-1-methyl ether

发表于由

天然产物醌类Quinones

Rubiadin-1-methyl ether 

Rubiadin-1-methyl ether 是巴戟天中的蒽醌类化合物，可抑制破骨细胞性骨吸收，通过抑制 NF-κB p65 磷酸化水平，降解 IκBα 蛋白，以及降低 p65 的核转位起作用。

Rubiadin-1-methyl ether

Rubiadin-1-methyl ether Chemical Structure

CAS No. : 7460-43-7

规格 价格 是否有货
1 mg ￥2000 询问价格 & 货期
5 mg ￥5000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].

IC50 & Target[1]

p65

 

分子量

268.26

Formula

C16H12O4
CAS 号

7460-43-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931.

Ferulic acid methyl ester(Synonyms: 阿魏酸甲酯; Methyl ferulate)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Ferulic acid methyl ester (Synonyms: 阿魏酸甲酯; Methyl ferulate) 纯度: 99.93%

Ferulic acid methyl ester (Methyl ferulate) 是从 Stemona tuberosa 中分到的阿魏酸衍生物，具有抗氧化、抗炎作用。Ferulic acid methyl ester 能够透过细胞膜和血脑屏障，清除自由基，可用于神经退行性疾病的研究。在原发性骨髓源性巨噬细胞中，Ferulic acid methyl ester 抑制 COX-2 的表达，降低 p-p38 和 p-JNK 的水平。

Ferulic acid methyl ester(Synonyms: 阿魏酸甲酯; Methyl ferulate)

Ferulic acid methyl ester Chemical Structure

CAS No. : 2309-07-1

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Ferulic acid methyl ester 相关产品

•相关化合物库:

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  • Immunology/Inflammation Compound Library
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  • Neurodegenerative Disease-related Compound Library
  • Angiogenesis Related Compound Library
  • Food-Sourced Compound Library

生物活性

Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2].

IC50 & Target[2]

p38

 

体外研究
(In Vitro)

Ferulic acid methyl ester (25 µg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h[2].
Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs)[2].
Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Primary bone marrow derived-macrophages (BMDMs)
Concentration: 25 µg/mL
Incubation Time: 6 h, 18 h, 48 h
Result: Showed no cytotoxic effects on BMDMs.

Western Blot Analysis[2]

Cell Line: RAW 246.7 cells
Concentration: 10 µg/mL and 25 µg/mL
Incubation Time: For 1 h before stimulation with LPS
Result: Significantly suppressed COX-2 expression at 25 µg/mL.

分子量

208.21

Formula

C11H12O4
CAS 号

2309-07-1
中文名称

阿魏酸甲酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (480.28 mM)

H2O : 2 mg/mL (9.61 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.8028 mL 24.0142 mL 48.0284 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL
10 mM 0.4803 mL 2.4014 mL 4.8028 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (12.01 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (12.01 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (12.01 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Sultana R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochim Biophys Acta. 2012 May;1822(5):748-52.

    [2]. Phuong NT, et al. Anti-inflammatory activity of methyl ferulate isolated from Stemona tuberosa Lour. Asian Pac J Trop Med. 2014 Sep;7S1:S327-31.

Methyl rosmarinate

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Methyl rosmarinate  纯度: 99.89%

Methyl rosmarinate 是一种从 Rabdosia serra 中分离得到的非竞争性 tyrosinase 抑制剂，对蘑菇酪氨酸酶作用的 IC50 值为 0.28 mM，也能抑制 a-glucosidase[1]。

Methyl rosmarinate

Methyl rosmarinate Chemical Structure

CAS No. : 99353-00-1

规格 价格 是否有货 数量
5 mg ￥2350 In-stock
10 mg ￥4000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Methyl rosmarinate 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Food-Sourced Compound Library

生物活性

Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1].

IC50 & Target

IC50: 0.28 mM (mushroom tyrosinase), a -glucosidase[1]
分子量

374.34

Formula

C19H18O8
CAS 号

99353-00-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (267.14 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6714 mL 13.3568 mL 26.7137 mL
5 mM 0.5343 mL 2.6714 mL 5.3427 mL
10 mM 0.2671 mL 1.3357 mL 2.6714 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.68 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.68 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.68 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Lin L, et al. Comparative evaluation of rosmarinic acid, methyl rosmarinate and pedalitin isolated from Rabdosia serra (MAXIM.) HARA as inhibitors of tyrosinase and α-glucosidase. Food Chem. 2011 Dec 1;129(3):884-9.