Pepinh-TRIF TFA

发表于由

Pepinh-TRIF TFA;

Pepinh-TRIF (TFA) 是一种 30 aa 肽，通过干扰 TLR-TRIF 的相互作用 (TLR-TRIF interaction ) 来阻断 TRIF 信号。

Pepinh-TRIF TFAamp;;

Pepinh-TRIF TFA Chemical Structure

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生物活性

Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction[1].

体外研究
(In Vitro)

Pepinh-TRIF (40 μM, 6 hours) blocks the expression and production of IL-33 stimulated by polyI:C or flagellin, and also greatly suppresses the stimulated IκB-α phosphorylation and degradation in HCECs[1].
Pepinh-TRIF (40 μM, 6 hours) suppresses NF-κB activation with p65 protein nuclear translocation [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HCECs
Concentration: 40 μM
Incubation Time: 6 hours
Result: Blocked NF-κB activation with p65 nuclear translocation.

分子量

4016.63

Formula

C180H279F3N58O40S2
Sequence Shortening

RQIKIWFQNRRMKWKKFCEEFQVPGRGELH-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Amal Hasan, et al. TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation. Int J Mol Sci. 2019 Aug 23;20(17):4112.