HIF-1 alpha (556-574)

发表于2023年2月15日由Whatman官网

HIF-1 alpha (556-574);

HIF-1 alpha (556-574) 是缺氧诱导因子-1 (HIF-1) 的 19 个氨基酸短肽段。HIF-1 是对氧稳态响应的主要调节剂。

HIF-1 alpha (556-574) Chemical Structure

CAS No. : 1201633-99-9

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性

HIF-1 alpha (556-574) is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis^[1].

分子量

2254.60

Formula

C₁₀₁H₁₅₀D₂N₂₀O₃₄S₂

CAS 号

1201633-99-9

Sequence Shortening

DLDLEMLAPYIPMDDDFQL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Ehrismann D, et al. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J. 2007 Jan 1;401(1):227-34.

HIF-1 alpha (556-574) (TFA)

发表于2023年1月29日由Whatman官网

HIF-1 alpha (556-574) (TFA);

HIF-1 alpha (556-574) TFA 是缺氧诱导因子-1 (HIF-1) 的 19 个氨基酸短肽段。HIF-1 是对氧稳态响应的主要调节剂。

HIF-1 alpha (556-574) (TFA) Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性

HIF-1 alpha (556-574) TFA is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis^[1].

分子量

2368.62

Formula

C₁₀₃H₁₅₁D₂F₃N₂₀O₃₆S₂

Sequence Shortening

DLDLEMLAPYIPMDDDFQL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Ehrismann D, et al. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J. 2007 Jan 1;401(1):227-34.

Insulin alpha-chain (1-13)

发表于2023年1月24日由Whatman官网

Insulin alpha-chain (1-13);

Insulin alpha-chain (1-13) 是一种人白细胞抗原 HLA-DR4 限制性表位，由胰岛素 A 链的前 13 个氨基酸组成。

Insulin alpha-chain (1-13) Chemical Structure

CAS No. : 872036-64-1

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性	Insulin alpha-chain (1-13) is a human leucocyte antigen (HLA)-DR4-restricted epitope comprising the first 13 amino acids of the insulin A-chain^[1].
分子量	1639.96
Formula	C₆₆H₁₁₈N₂₀O₂₂S₃
CAS 号	872036-64-1
Sequence	Lys-Arg-Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu
Sequence Shortening	KRGIVEQCCTSICSL
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Mannering SI, et al. The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes. Clin Exp Immunol. 2009 May;156(2):226-31.

Alpha 1(I) Collagen (614-639), human

发表于2023年1月7日由Whatman官网

Alpha 1(I) Collagen (614-639), human;

Alpha 1(I) Collagen (614-639), human 是一种 alpha-I 型胶原蛋白多肽片段。

Alpha 1(I) Collagen (614-639), human Chemical Structure

CAS No. : 210905-12-7

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性

Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.

分子量

2942.16

Formula

C₁₃₄H₁₈₉N₃₇O₃₉

CAS 号

210905-12-7

Sequence

Ser-Ala-Gly-Phe-Asp-Phe-Ser-Phe-Leu-Pro-Gln-Pro-Pro-Gln-Glu-Lys-Ala-His-Asp-Gly-Gly-Arg-Tyr-Tyr-Arg-Ala

Sequence Shortening

SAGFDFSFLPQPPQEKAHDGGRYYRA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

ChristAlpha1-4/2-4LSC实验室高级型冻干机

发表于2022年12月5日由Whatman官网

Christ Alpha 1-4/2-4 LSC 实验室高级型冻干机

产品编号：
市场价：~~￥0.00~~元
会员价：￥0.00元
品牌：Christ
生产厂家：Christ
需求数量：

产品概览
技术参数
订购信息
相关资料

相关产品

Christ Alpha 1-4/2-4 LSC 实验室高级型冻干机应用领域：

冷冻干燥主要应用于干燥对热敏感、受热易变性的物质，如血清、疫苗、微生物、组织等生物样品，可保持样品原来的形状和结构，便于储存；还可应用于比表面积大的物质如纳米级颗粒物质等，能够最大限度的保持样品的表面积。

Christ Alpha 1-4/2-4 LSC 实验室高级型冻干机配置特点：

1. Process A：一层可控温搁板，Ø 200mm，面积0.031m2,一层可控温压盖装置，Ø 200mm，面积0.031m2

2. 选择叠加干燥腔，最多可选24个独立控制的外接口，用于连接圆底烧瓶、广口过滤瓶和安瓿分配器（15个接口）

3. 可选带8个橡胶阀外接口的多歧管，用于连接圆底烧瓶、广口过滤瓶和安瓿分配器

4. 可选10层可加热搁板，Ø 200mm，面积0.31m2,搁板间距25mm，可另选12个独立控制的外接口

5. 可选四层压盖装置，Ø 250mm，面积0.18m2,搁板间距50mm

6.可选五层搁板，Ø 375mm，面积0.55m2,搁板间距67mm

7.可选电动有机玻璃干燥腔提升装置，缓慢控制启动/终止，实现平缓提升/下降

8. 可选防腐蚀设计扩展

控制器特点：

LSC 控制器除了具有LD Plus 的特点外，还有以下特点：

1. 1/4VGA（视频图形阵列）液晶大屏幕显示，图形用户界面，具有单键飞梭功能，直观图形形象地显示冻干机以及真空系统工作状态（如果处于运行状态，则为填充状）

2. 可显示和控制步骤状态、步骤时间、搁板温度、真空度、安全压力、升温速度等参数，

3. 精确控制整个冻干过程的每个细节，并可实现冻干各阶段自动跳转

4. 可对冻干过程实现完全手动控制，时间将不可设定

5. 可选配Lyocontrol LC-1共晶点测试系统能记录样品在整个冻干过程中温度和电阻的变化进而确定样品的共晶点，由此可确定冻干的工艺参数，从而优化冻干条件，提高冻干效率，这些数据也可被整合于自动压力控制中

6. 可选程序模块PGM-30，作为LSC控制器的功能扩展，可编制多达30个干燥程序，将整个冻干过程分为15步，为每个阶段提供更多的步骤控制，可快速导入、编辑、保存和删除程序

7. 通过设定搁板温度和样品温度之间的Delta-t，更好的控制冻干的进行

8. 可提示并记录错误操作的信息

9. 可通过配备电动中间阀实现自动终点控制（process B）

10. 可选配过程控制系统LPC-32 LSC，通过该软件可实现电脑与冻干机之间的数据传输以及电脑监控

技术参数：

1. 台式空冷系统，制冷功率：0.51kW（2×0.51kW）

2. 无氟环保制冷剂：CFC and H-CFC-free；

3. 最大凝冰量：4Kg；凝冰效率4kg/24h

4. 冷凝室最低温度：－60℃（－85℃）,容量：6.5L

5. 尺寸（mm）：W390×H415×D555（W390×H415×D555）

6. 重量（kg）：48(60)

7. 电源/功率/电流：230V, 50-60Hz/1.8(2.5)KVA

Santonin(Synonyms: 山道年; Alpha-Santonin)

发表于2022年11月28日由Whatman官网

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Santonin (Synonyms: 山道年; Alpha-Santonin) 纯度: 99.80%

Santonin (Alpha-Santonin) 是 Artemisia cina 的活性成分，可用于研究蠕虫感染。

Santonin Chemical Structure

CAS No. : 481-06-1

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥550	In-stock
500 mg	￥500	In-stock
1 g		询价
5 g		询价

* Please select Quantity before adding items.

Santonin 相关产品

•相关化合物库:

Covalent Screening Library Plus
Natural Product Library Plus
Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
FDA-Approved Drug Library Mini
Bioactive Compound Library Plus
Anti-Infection Compound Library
Natural Product Library
FDA-Approved Drug Library
Drug Repurposing Compound Library
Covalent Screening Library
NMPA-Approved Drug Library
Terpenoids Library
Orally Active Compound Library
Traditional Chinese Medicine Monomer Library
FDA Approved & Pharmacopeial Drug Library
Antiparasitic Compound library
Food-Sourced Compound Library

生物活性

Santonin is an active principle of the plant Artemisia cina, which is formely used to treat worms^[1].

分子量

246.30

Formula

C₁₅H₁₈O₃

CAS 号

481-06-1

中文名称

山道年；蛔蒿素；散道宁

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL (253.76 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.0601 mL	20.3004 mL	40.6009 mL
5 mM	0.8120 mL	4.0601 mL	8.1202 mL
10 mM	0.4060 mL	2.0300 mL	4.0601 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (8.44 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (8.44 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (8.44 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (8.44 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (8.44 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (8.44 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Sakipova Z, et al. Quantification of santonin in eight species of Artemisia from Kazakhstan by means of HPLC-UV: Method development and validation. PLoS One. 2017 Mar 16;12(3):e0173714.

alpha-Boswellic acid(Synonyms: α-乳香酸; α-Boswellic acid)

发表于2022年11月27日由Whatman官网

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

alpha-Boswellic acid (Synonyms: α-乳香酸; α-Boswellic acid) 纯度: 98.40%

alpha-Boswellic acid (α-Boswellic acid) 是一种五环三萜类化合物，从乳香中提取，具有抗惊厥和抗癌活性。α- boswellic acid 可在动物体内，预防和减少阿尔茨海默病标志物，可用于阿尔茨海默病的研究。

alpha-Boswellic acid Chemical Structure

CAS No. : 471-66-9

规格	价格	是否有货
5 mg	￥2550	In-stock
10 mg	￥3200	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

alpha-Boswellic acid 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Lipid Compound Library
Terpenoids Library
Traditional Chinese Medicine Monomer Library
Anti-Alzheimer’s Disease Compound Library
Neurodegenerative Disease-related Compound Library

生物活性

alpha-Boswellic acid (α-Boswellic acid) is a pentacyclic triterpene compound from extracts of Frankincense, has anticonvulsant and anti-cancer properties^[1]. alpha-Boswellic acid prevents and decreases the progression of Alzheimer’s hallmarks in vivo and can be used for Alzheimer’s disease research^[2].

分子量

456.70

Formula

C₃₀H₄₈O₃

CAS 号

471-66-9

中文名称

α-乳香酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 25 mg/mL (54.74 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1896 mL	10.9481 mL	21.8962 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL
10 mM	0.2190 mL	1.0948 mL	2.1896 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: 2.5 mg/mL (5.47 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (5.47 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.47 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (5.47 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.47 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.47 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. G.G. Allan, et al. The 18α-epimer of α-boswellic acid: conformational diagnosis of triterpenoids by ultraviolet absorption spectroscopy. Phytochemistry Volume 10, Issue 6, June 1971, Pages 1363–1366

alpha-Cyperone(Synonyms: α-Cyperone; (+)-α-Cyperone)

发表于2022年11月24日由Whatman官网

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

alpha-Cyperone (Synonyms: α-Cyperone; (+)-α-Cyperone) 纯度: 99.12%

alpha-Cyperone (α-Cyperone) 与 Cox-2, IL-6, Nck-2, Cdc42, Rac1 的表达下调相关,从而能够降低炎症反应。

alpha-Cyperone Chemical Structure

CAS No. : 473-08-5

规格	价格	是否有货
5 mg	￥550	In-stock
10 mg	￥880	In-stock
25 mg	￥1800	In-stock
50 mg	￥3200	In-stock
100 mg		询价
200 mg		询价

* Please select Quantity before adding items.

alpha-Cyperone 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus

生物活性

alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

The anti-inflammatory activity of alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells^[1].
alpha-Cyperone (α-Cyperone) binds and interacts with tubulin and is capable of distinctly destabilizing microtubule polymerization. The effect of this interaction could result in reduction of inflammation which would be highly beneficial for treatment of inflammatory diseases such as AD. One microliter of alpha-Cyperone was dissolved in DMSO (1:1 v/v) and it was further diluted in double distilled water (ddH2O) to a final volume of 20 microliter^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

218.33

Formula

C₁₅H₂₂O

CAS 号

473-08-5

中文名称

α-香附酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

In Vitro:

Ethanol : 140 mg/mL (641.23 mM; Need ultrasonic)

DMSO : 100 mg/mL (458.02 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.5802 mL	22.9011 mL	45.8022 mL
5 mM	0.9160 mL	4.5802 mL	9.1604 mL
10 mM	0.4580 mL	2.2901 mL	4.5802 mL

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% saline

Solubility: 3.5 mg/mL (16.03 mM); Suspended solution; Need ultrasonic

此方案可获得 3.5 mg/mL (16.03 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 35.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% EtOH 90% (20% SBE-β-CD in saline)

Solubility: 3.5 mg/mL (16.03 mM); Suspended solution; Need ultrasonic

此方案可获得 3.5 mg/mL (16.03 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 35.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% EtOH 90% corn oil

Solubility: ≥ 3.5 mg/mL (16.03 mM); Clear solution

此方案可获得 ≥ 3.5 mg/mL (16.03 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 35.0 mg/mL 的澄清 EtOH 储备液加到 900 μL玉米油中，混合均匀。
4.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (11.45 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
5.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (11.45 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
6.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (11.45 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Jung, S. H. et al. alpha-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFkappaB signalling in RAW 264.7 cells. Journal of ethnopharmacology 147, 208-214, doi:10.1016/j.jep.2013.02.034 (2013).

[2]. Azimi, A. et al. alpha-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain. Journal of ethnopharmacology, doi:10.1016/j.jep.2016.06.058 (2016).

alpha-Asarone(Synonyms: α-Asarone; trans-Asarone)

发表于2022年11月18日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

alpha-Asarone (Synonyms: α-Asarone; trans-Asarone) 纯度: 99.57%

alpha-Asarone (α-Asarone) 是菖蒲属中主要的活性物质，具有抗抑等功效。

alpha-Asarone Chemical Structure

CAS No. : 2883-98-9

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥550	In-stock
500 mg	￥500	In-stock
1 g	￥700	In-stock
5 g	￥1500	In-stock
10 g		询价
50 g		询价

* Please select Quantity before adding items.

alpha-Asarone 相关产品

•相关化合物库:

Natural Product Library Plus
Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
Bioactive Compound Library Plus
Membrane Transporter/Ion Channel Compound Library
Neuronal Signaling Compound Library
Natural Product Library
FDA-Approved Drug Library
Drug Repurposing Compound Library
NMPA-Approved Drug Library
Neurotransmitter Receptor Compound Library
Traditional Chinese Medicine Monomer Library
FDA Approved & Pharmacopeial Drug Library
Anti-Alzheimer’s Disease Compound Library
Neuroprotective Compound Library
Anti-Parkinson’s Disease Compound Library
Neurodegenerative Disease-related Compound Library
Food-Sourced Compound Library

生物活性

alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.

体外研究
(In Vitro)

The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

208.25

Formula

C₁₂H₁₆O₃

CAS 号

2883-98-9

中文名称

α-细辛脑；α-细辛醚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (480.19 mM; Need ultrasonic)

H₂O : 0.67 mg/mL (3.22 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.8019 mL	24.0096 mL	48.0192 mL
5 mM	0.9604 mL	4.8019 mL	9.6038 mL
10 mM	0.4802 mL	2.4010 mL	4.8019 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (12.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.00 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.00 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.00 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Ranjithkumar Chellian, et al. Biphasic Effects of α-Asarone on Immobility in the Tail Suspension Test: Evidence for the Involvement of the Noradrenergic and Serotonergic Systems in Its Antidepressant-Like Activity. Front Pharmacol. 2016; 7: 72.

[2]. Byung-Wook Kim, et al. α-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson’s disease. Neuropharmacology, Volume 97, October 2015, Pages 46–57

[3]. Hye-Jung Park, et al. Effect of α-asarone on angiogenesis and matrix metalloproteinase. Environmental Toxicology and Pharmacology, Volume 39, Issue 3, May 2015, Pages 1107–1114

alpha-D-glucose

发表于2022年11月1日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

alpha-D-glucose; 纯度: ge;99.0%

alpha-D-glucose 是一种内源性代谢产物。

alpha-D-glucose Chemical Structure

CAS No. : 492-62-6

规格	价格	是否有货	数量
Free Sample (0.1-0.5 mg)	;	Apply now	;
10;mM;*;1 mL in DMSO	￥660	In-stock
100 mg	￥600	In-stock
200 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

alpha-D-glucose 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Natural Product Library
Human Endogenous Metabolite Compound Library
Traditional Chinese Medicine Monomer Library
Gut Microbial Metabolite Library
Microbial Metabolite Library
Food-Sourced Compound Library

生物活性

alpha-D-glucose is an endogenous metabolite.

IC₅₀ Target

Human Endogenous Metabolite

;

分子量

180.16

Formula

C₆H₁₂O₆

CAS 号

492-62-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (555.06 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.5506 mL	27.7531 mL	55.5062 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: 2.5 mg/mL (13.88 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (13.88 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (13.88 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (13.88 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (13.88 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (13.88 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

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沃特曼官网代理商|Whatman滤纸滤膜中国官网代理商

标签归档：alpha

HIF-1 alpha (556-574)

HIF-1 alpha (556-574) (TFA)

Insulin alpha-chain (1-13)

Alpha 1(I) Collagen (614-639), human

ChristAlpha1-4/2-4LSC实验室高级型冻干机

Christ Alpha 1-4/2-4 LSC 实验室高级型冻干机

Santonin(Synonyms: 山道年; Alpha-Santonin)

Santonin 相关产品

•相关化合物库:

alpha-Boswellic acid(Synonyms: α-乳香酸; α-Boswellic acid)

alpha-Boswellic acid 相关产品

•相关化合物库:

alpha-Cyperone(Synonyms: α-Cyperone; (+)-α-Cyperone)

alpha-Cyperone 相关产品

•相关化合物库:

alpha-Asarone(Synonyms: α-Asarone; trans-Asarone)

alpha-Asarone 相关产品

•相关化合物库:

alpha-D-glucose

alpha-D-glucose 相关产品

bull;相关化合物库: