CMD178

CMD178;

CMD178 是一种重要的多肽,能够持续地通过抑制 IL-2/s IL-2Rα 信号通路来减少 Foxp3 和 STAT5 的表达。CMD 178 是 STAT5 的抑制剂, 并可抑制 Treg 细胞的发育。

CMD178amp;;

CMD178 Chemical Structure

规格 是否有货
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CMD178 的其他形式现货产品:

CMD178 TFA

生物活性

CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling. CMD178 also is an inhibitor of STAT5 and inhibit Treg cell development[1].

分子量

850.03

Formula

C7H7F2KOY

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Price-Troska T, et al. Inhibiting IL-2 signaling and the regulatory T-cell pathway using computationally designed peptides. Invest New Drugs. 2018 Apr 26.

AF12198

AF12198; 纯度: 99.61%

AF12198 是针对人类I型白介素-1 受体 (IL1R1) (IC50=8 nM) 的有效,选择性和特异性肽拮抗剂,但不是针对人类 II 型受体 (IC50=6.7 µM) 或鼠 I 型受体 (IC50>200 µM)。AF12198 抑制 IL-1 诱导的 IL-8 产生 (IC50=25 nM) 和 IL-1诱导的细胞间粘附分子 1 (ICAM-1) 表达 (IC50=9 nM)。AF12198 具有抗炎活性,并在体内阻断了对 IL-1 的反应。

AF12198amp;;

AF12198 Chemical Structure

CAS No. : 185413-30-3

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1 mg ¥1200 In-stock
5 mg ¥3500 In-stock
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AF12198 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1].

IC50 Target[1]

IL1R1

8 nM (IC50)

体外研究
(In Vitro)

AF12198 competes for binding of 125I-IL-1α with an IC50 of 8.0 nM, nearly equal to that of IL-1ra, IC50 of 4.0 nM for the type I receptor[1].
AF12198 (0-5 ng; 8 hours) inhibits IL-6 induction with an IC50 of 15 μM whereas IL-1ra inhibits with an IC50 of 2 nM in heparinized human primate blood. Meanwhile, With blood from cynomolgus monkeys, the IC50 values are 17 μM for AF12198 and 30 nM for IL-1ra. Additionally, AF12198 or IL-1RA alone does not induce IL-6 in blood from either humans or cynomolgus monkeys[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

AF12198 (intravenous infusion; 16 mg/kg; 30 min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4 h (32.6%), 12 h (50.1%) and 24 h (65.3%) after LPS[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[2]
Dosage: 16 mg/kg
Administration: Intravenous infusion; 30 min before LPS intravenous injection
Result: Decreased pulmonary microvascular leakage in rats.

分子量

1895.12

Formula

C96H123N19O22

CAS 号

185413-30-3

Sequence

Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-{Aze}-Tyr-Ala-Leu-Pro-Leu-NH2

Sequence Shortening

Ac-FEWTPGWYQ-{Aze}-YALPL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (52.77 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5277 mL 2.6384 mL 5.2767 mL
5 mM 0.1055 mL 0.5277 mL 1.0553 mL
10 mM 0.0528 mL 0.2638 mL 0.5277 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (1.32 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.32 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.32 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.32 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. F Aimbire, et al. Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1beta levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation

    [2]. A L Akeson, et al.AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J Biol Chem. 1996 Nov 29;271(48):30517-23.

β-Anhydroicaritin

天然产物 黄酮类 Flavonoids

β-Anhydroicaritin  纯度: 98.43%

β-Anhydroicaritin 提取自 Boswellia carterii Birdware,具有重要的生物学和药理学作用,例如抗骨质疏松症,雌激素调节和抗肿瘤特性。β-Anhydroicaritin 改善牙周组织的降解,抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。β-Anhydroicaritin 减少腹膜炎小鼠 NO,IL-10,TNF-α,MCP-1 和 IL-6 的过量产生。β-Anhydroicaritin 抑制细胞内 Ca2+ 的升高,并显着降低 iNOS 蛋白的表达。

β-Anhydroicaritin

β-Anhydroicaritin Chemical Structure

CAS No. : 38226-86-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥660 In-stock
5 mg ¥600 In-stock
10 mg ¥1000 In-stock
20 mg ¥1800 In-stock
50 mg   询价  
100 mg   询价  

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β-Anhydroicaritin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Differentiation Inducing Compound Library
  • Diabetes Related Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Anti-Pancreatic Cancer Compound Library
  • Angiogenesis Related Compound Library

生物活性

β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats[2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].

IC50 & Target[1][2][3]

IL-10

 

IL-6

 

TNF-α

 

MMP-3

 

分子量

368.38

Formula

C21H20O6

CAS 号

38226-86-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 8.33 mg/mL (22.61 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7146 mL 13.5729 mL 27.1459 mL
5 mM 0.5429 mL 2.7146 mL 5.4292 mL
10 mM 0.2715 mL 1.3573 mL 2.7146 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Nguyen VS, et al. Synthesis of Icaritin and β-anhydroicaritin Mannich Base Derivatives and Their Cytotoxic Activities on Three Human Cancer Cell Lines. Anticancer Agents Med Chem. 2017;17(1):137-142

    [2]. Wu Y, et al. Effect of β-anhydroicaritin on the expression levels of tumor necrosis factor-α and matrix metalloproteinase-3 in periodontal tissue of diabetic rats. Mol Med Rep. 2015 Aug;12(2):1829-37.

    [3]. Lai X, et al. Protective effect of anhydroicaritin against peritonitis in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Oct;29(10):1036-9.

Ginsenoside F3

天然产物 糖类和糖苷 Saccharides and Glycosides

Ginsenoside F3; 纯度: 99.84%

Ginsenoside F3 是从 Panax ginseng 叶片中提取的皂苷,通过调节1 型 (IL-2, IFN-γ) 和 2 型细胞因子(IL-4 and IL-10) 的产生和表达,发挥免疫增强活性。

Ginsenoside F3

Ginsenoside F3 Chemical Structure

CAS No. : 62025-50-7

规格 价格 是否有货 数量
1 mg ¥1350 In-stock
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Ginsenoside F3 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Kinase Inhibitor Library
  • Natural Product Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Pyroptosis Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Angiogenesis Related Compound Library
  • Food-Sourced Compound Library

生物活性

Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10)[1].

IC50 Target[1]

IL-2

;

IL-4

;

IL-10

;

分子量

770.99

Formula

C41H70O13

CAS 号

62025-50-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. Yu JL, et al. Immunoenhancing activity of protopanaxatriol-type ginsenoside-F3 in murine spleen cells. Acta Pharmacol Sin. 2004 Dec;25(12):1671-6.

Isoforskolin(Synonyms: Coleonol B)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Isoforskolin (Synonyms: Coleonol B)

Isoforskolin 是原产于中国的 C. forskohlii 的主要活性成分。在人单核白细胞中,Isoforskolin 减少了脂多糖 (LPS) 诱导的细胞因子如 TNF-αIL-1βIL-6IL-8 的分泌。Isoforskolin 可作为抗炎剂,有潜力用于莱姆关节炎的研究。

Isoforskolin(Synonyms: Coleonol B)

Isoforskolin Chemical Structure

CAS No. : 64657-21-2

规格 价格 是否有货 数量
1 mg ¥2290 In-stock
5 mg ¥6860 In-stock
10 mg   询价  
50 mg   询价  

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Isoforskolin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis[1].

IC50 & Target

TNF-α

 

IL-1β

 

IL-6

 

IL-8

 

体外研究
(In Vitro)

Isoforskolin downregulates the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

410.50

Formula

C22H34O7

CAS 号

64657-21-2

中文名称

异佛司可林;异佛斯可林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Zhao H, et al. Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A.Exp Ther Med. 2017 Dec;14(6):5974-5980.

Catalposide

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Catalposide  纯度: ≥98.0%

Catalposide 是可从 Catalpa ovate G. Don 分离得到的环烯醚萜苷,可抑制 LPS 诱导的TNF-α、IL-1β、IL-6 和 NF-κB (p65) 的活化。

Catalposide

Catalposide Chemical Structure

CAS No. : 6736-85-2

规格 价格 是否有货 数量
1 mg ¥2800 In-stock
5 mg ¥9800 In-stock
10 mg   询价  
50 mg   询价  

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生物活性

Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages[1].

体外研究
(In Vitro)

Catalposide (1-1000 ng/mL) could inhibit TNF-a, IL-1β, and IL-6 productions in RAW 264.7 macrophages[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

482.43

Formula

C22H26O12

CAS 号

6736-85-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. S J An, et al. Inhibition of TNF-alpha, IL-1beta, and IL-6 productions and NF-kappa B activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). Int Immunopharmacol. 2002 Jul;2(8):1173-81.

Interleukin (IL)-6 Receptor(Synonyms: 白细胞介素 (IL)-6 受体)

Interleukin (IL)-6 Receptor;(Synonyms: 白细胞介素 (IL)-6 受体) 纯度: 98.20%

Interleukin (IL)-6 Receptor 是一种多肽,来源于白细胞介素6受体。

Interleukin (IL)-6 Receptoramp;;(Synonyms: 白细胞介素 (IL)-6 受体)

Interleukin (IL)-6 Receptor Chemical Structure

规格 价格 是否有货 数量
1 mg ¥1200 In-stock
5 mg ¥4800 In-stock
10 mg ¥8100 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Interleukin (IL)-6 Receptor 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Interleukin (IL)-6 Receptor is a peptide, derived from interleukin-6 receptor.

分子量

1216.30

Formula

C51H85N13O21

Sequence

Thr-Ser-Leu-Pro-Val-Gln-Asp-Ser-Ser-Ser-Val-Pro

Sequence Shortening

TSLPVQDSSSVP

中文名称

白细胞介素 (IL)-6 受体

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 50 mg/mL (41.11 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8222 mL 4.1108 mL 8.2217 mL
5 mM 0.1644 mL 0.8222 mL 1.6443 mL
10 mM 0.0822 mL 0.4111 mL 0.8222 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。