标签归档：factor

Thymus factor X(Synonyms: 胸腺因子X TFX-Jelfa)

发表于由

Thymus factor X;(Synonyms: 胸腺因子X; TFX-Jelfa) 纯度: ge;98.0%

Thymic factor X (TFX-Jelfa) 是一种来自幼年小牛胸腺的水提取物，也是一种天然的淋巴细胞功能刺激剂。

Thymus factor Xamp;;(Synonyms: 胸腺因子X; TFX-Jelfa)

Thymus factor X Chemical Structure

CAS No. : 78310-77-7

规格 价格 是否有货 数量
1 mg ￥1800 In-stock
5 mg ￥7200 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Thymus factor X 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Thymic factor X (TFX-Jelfa) is an aqueous extract from juvenile calf thymuses and a natural stimulator of lymphocyte function[1][2].

体内研究
(In Vivo)

The percentage of necrotic lymphocytes in the spleen in Group I (infected with T. spiralis and treated with Thymus factor X (TFX)) is significantly lower than in the control group on day 7, and approximately the same as in the control group for the rest of the experiment. The percentage of necrotic lymphocytes in muscle tissue in Group I is approximately the same as in the control group on day 7, significantly lower on days 14 and 21 (p<0.0002), approximately the same on days 28 and 35, significantly lower on day 42, and significantly higher on day 60 (p<0.005)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号

78310-77-7
中文名称

胸腺因子X
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Piekarska J, et al. Trichinella spiralis: Effect of thymus factor X on apoptosis and necrosis in mice. Exp Parasitol. 2009 Oct;123(2):128-33.

    [2]. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). Med Oncol Tumor Pharmacother. 1989;6(1):31-43.
Animal Administration
[1]

The experiment is carried out using 134 mice divided into three groups: Group I: 46 mice infected with T. spiralis and treated with Thymus factor X (TFX); Group II: 42 uninfected mice treated with Thymus factor X; and Control group: 46 mice infected with T. spiralis and not treated with Thymus factor X. Thymus factor X is administered subcutaneously at a dose of 15 mg/kg. The first dose is administered on the third day before the mice are infected with T. spiralis. The dose is repeated at 24 h intervals until the thirteenth day after infection. In all, 17 doses are administered. On days 7, 14, 21, 28, 35, 42, and 60 after infection, six mice from each group are sacrificed using halothane. The spleen, mesenteric lymph nodes and masseter muscles are excised from each mouse and transferred to sterile phospho-buffered saline at 4°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Piekarska J, et al. Trichinella spiralis: Effect of thymus factor X on apoptosis and necrosis in mice. Exp Parasitol. 2009 Oct;123(2):128-33.

    [2]. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). Med Oncol Tumor Pharmacother. 1989;6(1):31-43.

Euphorbia Factor L1(Synonyms: 大戟因子 L1)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Euphorbia Factor L1 (Synonyms: 大戟因子 L1) 纯度: 99.69%

Euphorbia Factor L1 是续随子中的二萜类化合物，可降低 Bcl-2，PI3K，AKT 和 mTOR 蛋白和 mRNA 水平，上调 caspase-9 and caspase-3 蛋白水平，但对 caspase-9 和 caspase-3 蛋白酶原无影响。Euphorbia Factor L1 可诱导自噬 (apoptosis)，具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。

Euphorbia Factor L1(Synonyms: 大戟因子 L1)

Euphorbia Factor L1 Chemical Structure

CAS No. : 76376-43-7

规格 价格 是否有货 数量
5 mg ￥990 In-stock
10 mg ￥1680 In-stock
20 mg ￥2860 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Euphorbia Factor L1 相关产品

•相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Covalent Screening Library
  • Anti-Cardiovascular Disease Compound Library
  • Terpenoids Library

生物活性

Euphorbia Factor L1 is a diterpenoid from Euphorbia lathyris L., reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, buts shows no effect on pro-caspase-9 and pro-caspase-3. Euphorbia Factor L1 induces apoptosis, has anticancer, antiadipogenesis, antiosteoclastogenesis and multidrug resistance-modulating effect[1].

分子量

552.66

Formula

C32H40O8
CAS 号

76376-43-7
中文名称

大戟因子 L1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 10 mg/mL (18.09 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8094 mL 9.0472 mL 18.0943 mL
5 mM 0.3619 mL 1.8094 mL 3.6189 mL
10 mM 0.1809 mL 0.9047 mL 1.8094 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (4.52 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (4.52 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (1.81 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (1.81 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Zhu A, et al. Effect of euphorbia factor L1 on oxidative stress, apoptosis, and autophagy in human gastric epithelial cells. Phytomedicine. 2019 Apr 16;64:152929.

Tobramycin(Synonyms: 妥布霉素; Nebramycin Factor 6; Deoxykanamycin B)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Tobramycin;(Synonyms: 妥布霉素; Nebramycin Factor 6; Deoxykanamycin B) 纯度: ge;98.0%

Tobramycin (Nebramycin Factor 6) 是一种胃肠外给药的广谱氨基糖苷类抗生素，已广泛用于由于敏感生物引起的中度至重度细菌感染疾病的研究。

Tobramycin(Synonyms: 妥布霉素; Nebramycin Factor 6; Deoxykanamycin B)

Tobramycin Chemical Structure

CAS No. : 32986-56-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in Water ￥500 In-stock
100 mg ￥450 In-stock
500 mg ￥1023 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

* Please select Quantity before adding items.

Tobramycin 相关产品

bull;相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • FDA-Approved Drug Library
  • Drug Repurposing Compound Library
  • Covalent Screening Library
  • Glycoside Compound Library
  • Antibacterial Compound Library
  • Anti-COVID-19 Compound Library
  • NMPA-Approved Drug Library
  • Orally Active Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Antibiotics Library
  • Microbial Metabolite Library
  • Rare Diseases Drug Library

生物活性

Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms[1].

Clinical Trial

分子量

467.51

Formula

C18H37N5O9
CAS 号

32986-56-4
中文名称

妥布霉素；妥布拉霉素；托布拉霉素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 100 mg/mL (213.90 mM)

DMSO : 2 mg/mL (4.28 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1390 mL 10.6950 mL 21.3899 mL
5 mM 0.4278 mL 2.1390 mL 4.2780 mL
10 mM 0.2139 mL 1.0695 mL 2.1390 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Tobramycin.

α-Factor Mating Pheromone, yeast TFA(Synonyms: Mating Factor α TFA)

发表于由

α-Factor Mating Pheromone, yeast TFA;(Synonyms: Mating Factor α TFA)

α-Factor Mating Pheromone, yeast (TFA) 是一种十三肽，由 S. cerevisiae 的 α 细胞分泌产生，通过 Ste2p 受体起作用。

α-Factor Mating Pheromone, yeast TFAamp;;(Synonyms: Mating Factor α TFA)

α-Factor Mating Pheromone, yeast TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥800 In-stock
5 mg ￥2800 In-stock
10 mg ￥4800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

α-Factor Mating Pheromone, yeast (TFA) is a tridecapeptide secreted by S. cerevisiae α cells via Ste2p receptor[1].

分子量

1798.02

Formula

C84H115N20F3O19S
Sequence

Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr
Sequence Shortening

WHWLQLKPGQPMY
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. [1]. Naider F, et al. The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors. Peptides. 2004 Sep;25(9):1441-63.

Euphorbia factor L8

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Euphorbia factor L8 

Euphorbia factor L(8) 是大戟种子中的二萜。

Euphorbia factor L8

Euphorbia factor L8 Chemical Structure

CAS No. : 218916-53-1

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Euphorbia factor L(8) is a diterpenoid from the seeds of Euphorbia lathyris[1].

分子量

523.62

Formula

C30H37NO7
CAS 号

218916-53-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jiao W, et al. Euphorbia factor L(8): a diterpenoid from the seeds of Euphorbia lathyris. Acta Crystallogr Sect E Struct Rep Online. 2007;64(Pt 1):o331. Published 2007 Dec 21.

Euphorbia factor L7a

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Euphorbia factor L7a 

Euphorbia factor L7a 是一种二萜类化合物，是天然产物。

Euphorbia factor L7a

Euphorbia factor L7a Chemical Structure

CAS No. : 93550-94-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Euphorbia factor L7a, as a natural product, is a diterpenoid from the seeds of Euphorbia lathyris[1].

分子量

548.67

Formula

C33H40O7
CAS 号

93550-94-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hou XR, et al. Analysis and determination of diterpenoids in unprocessed and processed Euphorbia lathyris seeds by HPLC-ESI-MS. J Pharm Anal. 2011;1(3):197-202.

Euphorbia Factor L2(Synonyms: 大戟因子L2)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Euphorbia Factor L2 (Synonyms: 大戟因子L2) 纯度: 99.65%

Euphorbia factor L2 是从大戟种子中分离得到的一种赤藓烷二萜 (Euphorbia lathyris L.)，具有抗癌活性。Euphorbia factor L2 显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡。

Euphorbia Factor L2(Synonyms: 大戟因子L2)

Euphorbia Factor L2 Chemical Structure

CAS No. : 218916-51-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥4670 In-stock
5 mg ￥3300 In-stock
10 mg ￥5500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Euphorbia Factor L2 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Macrocyclic Compound Library
  • Terpenoids Library

生物活性

Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway[1].

分子量

642.73

Formula

C38H42O9
CAS 号

218916-51-9
中文名称

大戟因子L2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 83.33 mg/mL (129.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5559 mL 7.7793 mL 15.5586 mL
5 mM 0.3112 mL 1.5559 mL 3.1117 mL
10 mM 0.1556 mL 0.7779 mL 1.5559 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (9.72 mM); Clear solution

    此方案可获得 ≥ 6.25 mg/mL (9.72 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Lin M, et al. Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway. Acta Pharm Sin B. 2017 Jan;7(1):59-64.