MCH(human, mouse, rat)

发表于由

MCH(human, mouse, rat);

MCH (human, mouse, rat) 是一种有效的 MCH-R  的肽激动剂，与 MCH1R 和 MCH2R 结合的 IC50 值分别为 0.3nM 和 1.5 nM。MCH (human, mouse, rat) 对 CHO 细胞系中 MCH-2R 高度敏感，通过 FLIPR 监测细胞内钙动员，显示出功能性激活 MCH-1R 和 MCH-2R 的 EC50 值对分别为 3.9 nM 和 0.1 nM。

MCH(human, mouse, rat)amp;;

MCH(human, mouse, rat) Chemical Structure

CAS No. : 128315-56-0

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MCH(human, mouse, rat) 的其他形式现货产品:

MCH(human, mouse, rat) TFA

生物活性

MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively[1].

IC50 Target

Binding IC50: 0.3 nM (MCH1R)
IC50: 1.5 nM (MCH1R)[1]
分子量

2386.84

Formula

C105H160N30O26S4
CAS 号

128315-56-0
Sequence Shortening

DFDMLRCMLGRVYRPCWQV (Disulfide bridge:Cys7-Cys16)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.