CLIP (86-100)

发表于由

CLIP (86-100);

CLIP (86-100) 是 Ⅱ 类相关不变链肽 (CLIP) 的 86-100 个氨基酸片段。CLIP 是一个小的自体肽，也是位于 HLA-II 抗原结合区的固定链的裂解产物。通过与 Ⅱ 类肽结合位点的相互作用，CLIP 在 MHC Ⅱ 类 alphabetaIi 复合体的组装和转运中起着关键作用。

CLIP (86-100)amp;;

CLIP (86-100) Chemical Structure

CAS No. : 648881-58-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site[1].

分子量

1674.10

Formula

C72H128N20O19S3
CAS 号

648881-58-7
Sequence

Pro-Val-Ser-Lys-Met-Arg-Met-Ala-Thr-Pro-Leu-Leu-Met-Gln-Ala
Sequence Shortening

PVSKMRMATPLLMQA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. van Luijn MM, et al. Class II-associated invariant chain peptide as predictive immune marker in minimal residual disease in acute myeloid leukemia. Oncoimmunology. 2015 Jan 7;3(12):e941737. eCollection 2014 Dec.

    [2]. Thayer WP, et al. Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules. J Immunol. 1999 Feb 1;162(3):1502-9.