PHM-27 (human)

发表于由

PHM-27 (human);

PHM-27 (human) 是一种人类促血管活性的肠道多肽 (27 个氨基酸)。PHM-27 (human) 是一种有效的人降钙素受体 (human calcitonin receptor) 激动剂，EC50 为 11 nM。PHM-27 (human) 通过自分泌机制有效增强葡萄糖诱导的 β 细胞胰岛素分泌 。

PHM-27 (human)amp;;

PHM-27 (human) Chemical Structure

CAS No. : 87403-73-4

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生物活性

PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].

IC50 Target

EC50: 11 nM (human calcitonin receptor)[2]
分子量

2985.41

Formula

C135H214N34O40S
CAS 号

87403-73-4
Sequence

{His}{Ala}{Asp}{Gly}{Val}{Phe}{Thr}{Ser}{Asp}{Phe}{Ser}{Lys}{Leu}{Leu}{Gly}{Gln}{Leu}{Ser}{Ala}{Lys}{Lys}{Tyr}{Leu}{Glu}{Ser}{Leu}{Met}-NH2
Sequence Shortening

HADGVFTSDFSKLLGQLSAKKYLESLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. N Itoh, et al. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature. 1983 Aug 11-17;304(5926):547-9.

    [2]. Jian-Nong Ma, et al. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem Pharmacol. 2004 Apr 1;67(7):1279-84.

    [3]. I Kato, et al. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem. 1994 Aug 19;269(33):21223-8.