PAMP-12(human, porcine)

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PAMP-12(human, porcine)  纯度: 99.03%

PAMP-12(human, porcine) 是免疫反应性 (ir)-PAMP 的一种主要成分，由肾上腺髓质素前体加工而成，是一种有效的降压肽，可参与心血管方面的调控。

PAMP-12(human, porcine) 

PAMP-12(human, porcine) Chemical Structure

CAS No. : 196305-05-2

规格 价格 是否有货 数量
1 mg ￥1200 In-stock
5 mg ￥3600 In-stock
10 mg   询价  
50 mg   询价  

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PAMP-12(human, porcine) 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

PAMP-12(human, porcine) is a major component of immunoreactive (ir)-PAMP, is processed from the adrenomedullin precursor, is a potent hypotensive peptide and participates in cardiovascular control[1].

体外研究
(In Vitro)

PAMP-12 (human, porcine) is the PAMP[9-20] with a C-terminal amide structure. Intravenous injections of PAMP-12 in anesthetized rats show a significant hypotensive effect in a dose-dependent fashion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1618.93

Formula

C77H119N25O14
CAS 号

196305-05-2
Sequence Shortening

FRKKWNKWALSR-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. K Kuwasako, et al. Purification and Characterization of PAMP-12 (PAMP[9-20]) in Porcine Adrenal Medulla as a Major Endogenous Biologically Active Peptide. FEBS Lett. 1997 Sep 1;414(1):105-10.

  • [1]. K Kuwasako, et al. Purification and Characterization of PAMP-12 (PAMP[9-20]) in Porcine Adrenal Medulla as a Major Endogenous Biologically Active Peptide. FEBS Lett. 1997 Sep 1;414(1):105-10.