Ramoplanin(Synonyms: 雷莫拉宁)

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Ramoplanin;(Synonyms: 雷莫拉宁) 纯度: ge;92.0%

Ramoplanin 是一种源于 Actinoplanes spp 的糖肽类抗生素，具有抗革兰氏阳性菌活性。

Ramoplaninamp;;(Synonyms: 雷莫拉宁)

Ramoplanin Chemical Structure

CAS No. : 76168-82-6

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Ramoplanin 相关产品

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  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria[1][2].

IC50 Target

Bacteria[1]
体外研究
(In Vitro)

Ramoplanin exerts its bactericidal activity against gram-positive aerobic and anaerobic bacteria by blocking peptidoglycan synthesis via lipid II[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ramoplanin (100, 500 μg/ml; p.o.; for 8 days) suppresses vancomycin-resistant Enterococcus (VRE) to undetectable level during treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CF1 mice (25-30 g)[1]
Dosage: 100 μg/ml, 500 μg/ml
Administration: Oral administration; for 8 days
Result: Developed undetectable levels of VRE in stool during treatment.

CAS 号

76168-82-6
中文名称

雷莫拉宁
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Stiefel U, et al. Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice. Antimicrob Agents Chemother. 2004 Jun;48(6):2144-8.

    [2]. Cheng M, et al. Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus. Antimicrob Agents Chemother. 2014 Nov;58(11):6819-27.