天然产物 糖类和糖苷 Saccharides and Glycosides
Solamargine;(Synonyms: Solamargin; δ-Solanigrine) 纯度: ge;98.0%
Solamargine 是一种来源于茄属植物的类固醇 Solasodine 的衍生物,在多种癌症中均表现出抗癌活性。Solamargine 诱导非选择性细胞毒性和 P-gp 抑制作用。Solamargine 通过下调 MMP-2 和 MMP-9 的表达和活性来显着抑制 HepG2 细胞的迁移和侵袭。
Solamargine Chemical Structure
CAS No. : 20311-51-7
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥1719 | In-stock | |
5 mg | ¥1200 | In-stock | |
10 mg | ¥1800 | In-stock | |
50 mg | ¥6800 | In-stock | |
100 mg | ; | 询价 | ; |
200 mg | ; | 询价 | ; |
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Solamargine 相关产品
bull;相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Membrane Transporter/Ion Channel Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Glycoside Compound Library
- Lipid Compound Library
- Traditional Chinese Medicine Monomer Library
- Alkaloids Library
- Food-Sourced Compound Library
生物活性 |
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity[1][2]. |
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体外研究 (In Vitro) |
Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[3]
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体内研究 (In Vivo) |
Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
868.06 |
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Formula |
C45H73NO15 |
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CAS 号 |
20311-51-7 |
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中文名称 |
澳洲茄边碱;边缘茄碱 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : 100 mg/mL (115.20 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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