Polygalasaponin XXXI(Synonyms: Onjisaponin F)

天然产物 糖类和糖苷 Saccharides and Glycosides

Polygalasaponin XXXI;(Synonyms: Onjisaponin F) 纯度: 96.19%

Polygalasaponin XXXI (Onjisaponin F) 是鼻内注射流感 HA 疫苗的有效佐剂,可保护流感病毒感染

Polygalasaponin XXXI(Synonyms: Onjisaponin F)

Polygalasaponin XXXI Chemical Structure

CAS No. : 79103-90-5

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1 mg ¥1900 In-stock
5 mg ¥5710 In-stock
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生物活性

Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1].

体外研究
(In Vitro)

Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash, whereas Onjisaponins E and G enhances only anti-HA IgA Ab titer significantly. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus[1].
Polygalasaponin XXXI (Onjisaponin F) (1 or 10 µg/mL) also induces ChAT mRNA level in rat basal forebrain cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1589.67

Formula

C75H112O36

CAS 号

79103-90-5

中文名称

远志皂苷 F

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

参考文献
  • [1]. T Nagai, et al. Onjisaponins, From the Root of Polygala Tenuifolia Willdenow, as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34.

    [2]. T Yabe, et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia, Constituents of Kampo (Japanese Herbal) Medicine, Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14.