上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Quassin (Synonyms: Nigakilactone D)
Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum，IC50 为 0.15 μM。Quassin 具有可逆的避育能力，抗雌激素和抗疟原虫活性。
Quassin Chemical Structure
CAS No. : 76-78-8
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 1 mg | ￥2500 | 询问价格 & 货期 | |
| 5 mg | ￥6200 | 询问价格 & 货期 | |
| 10 mg | ￥9800 | 询问价格 & 货期 | |
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| 生物活性 |
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2]. |
IC50 & Target |
IC50: 0.15 μM (P. falciparum)[2] |
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| 体外研究 (In Vitro) |
Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
388.45 |
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| Formula |
C22H28O6 |
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| CAS 号 |
76-78-8 |
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| 中文名称 |
苦楝树甙,苦木素 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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