LEP(116-130)(mouse) | Cytiva思拓凡-Whatman滤纸滤膜滤器

LEP(116-130)(mouse) 纯度: 99.48%

LEP(116-130)(mouse) 是一种合成的瘦素肽片段。

LEP(116-130)(mouse) Chemical Structure

CAS No. : 258276-95-8

规格	价格	是否有货
1 mg	￥800	In-stock
5 mg	￥2400	In-stock
10 mg	￥3900	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

LEP(116-130)(mouse) 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

LEP(116-130)(mouse) is a synthetic leptin peptide fragment.

体外研究
(In Vitro)

LEP-(116-130) (300 µM) is unable to inhibit AP-OB binding^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

LEP-(116-130) (1 mg, i.p.) results in a reduced rate of body weight gain in the presence of increased food intake compared with vehicle-injcted control mice. LEP-(116-130) significantly reduces blood glucose levels by appr 100 mg/dL. Administration of LEP-(116-130) to wild-type (+/+) C57BLKS/J-m mice for 4 or 7 days has no effect on their ability to thermoregulate^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1560.73

Formula

C₆₄H₁₀₉N₁₉O₂₄S

CAS 号

258276-95-8

Sequence

Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2

Sequence Shortening

SCSLPQTSGLQKPES-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL (32.04 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.6407 mL	3.2036 mL	6.4073 mL
5 mM	0.1281 mL	0.6407 mL	1.2815 mL
10 mM	0.0641 mL	0.3204 mL	0.6407 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9.

Animal Administration ^[1]	Blood is drawn from the tail vein of each mouse 2 h before the onset of the dark period at the beginning of the study (day 0) and after 2, 4, and 6 days of treatment with 1 mg/day i.p. LEP-(116-130). Blood glucose levels are determined with a Glucometer Elite blood glucose monitor. After 4 and 7 days of treatment with 1 mg/day i.p. LEP-(116-130), sensitivity to cold is examined by placing the mice without food or water in a cold room with an ambient temperature of 4°C. Body temperature is measured with a rectal probe every hour for 4 h. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9.

Animal Administration
^[1]

Blood is drawn from the tail vein of each mouse 2 h before the onset of the dark period at the beginning of the study (day 0) and after 2, 4, and 6 days of treatment with 1 mg/day i.p. LEP-(116-130). Blood glucose levels are determined with a Glucometer Elite blood glucose monitor. After 4 and 7 days of treatment with 1 mg/day i.p. LEP-(116-130), sensitivity to cold is examined by placing the mice without food or water in a cold room with an ambient temperature of 4°C. Body temperature is measured with a rectal probe every hour for 4 h.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9.

[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9.