Alamandine 纯度: 98.95%
Alamandine 是一种血管活性肽,是肾素-血管紧张素系统 (RAS) 的成员,还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可通过抗高血压作用来保护肾脏和心脏。
Alamandine Chemical Structure
CAS No. : 1176306-10-7
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5 mg | ¥3800 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
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Alamandine 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
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- Metabolism/Protease Compound Library
- Anti-Cardiovascular Disease Compound Library
- Orally Active Compound Library
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- Angiogenesis Related Compound Library
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生物活性 |
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2]. |
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体外研究 (In Vitro) |
Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Alamandine (0.15 μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
855.00 |
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Formula |
C40H62N12O9 |
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CAS 号 |
1176306-10-7 |
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Sequence |
Ala-Arg-Val-Tyr-Ile-His-Pro |
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Sequence Shortening |
ARVYIHP |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
H2O : 25 mg/mL (29.24 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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[1]. Daniel C Villela, et al. Alamandine: a new member of the angiotensin family. Curr Opin Nephrol Hypertens. 2014 Mar;23(2):130-4.
[2]. Johanna Schleifenbaum. Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System. Front Med (Lausanne). 2019 Jun 11;6:107.
[3]. Chi Liu, et al. Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats. Amino Acids. 2018 Aug;50(8):1071-1081.