NGR peptide Trifluoroacetate(Synonyms: NGR肽三氟乙酸盐)

NGR peptide Trifluoroacetate;(Synonyms: NGR肽三氟乙酸盐) 纯度: ge;98.0%

NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽,NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。

NGR peptide Trifluoroacetateamp;;(Synonyms: NGR肽三氟乙酸盐)

NGR peptide Trifluoroacetate Chemical Structure

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ¥4770 In-stock
1 mg ¥1000 In-stock
5 mg ¥3000 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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NGR peptide Trifluoroacetate 相关产品

bull;相关化合物库:

  • Covalent Screening Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Covalent Screening Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature.

IC50 Target

CD13/aminopeptidase N (APN) receptor[1]

体外研究
(In Vitro)

NGR peptide can selectively bind to APN/CD13 either immune-captured or expressed on the surface of cells, the receptor of the tumor-homing NGR peptide was suspected to be APN/CD13. The NGR peptide is reported to have the greatest tumor selectivity. An anti-cancer drug Doxorubicin (DOX) coupled to an NGR peptide displays enhanced anti-tumor effects with even lower toxicity than the free drug itself[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

NGR peptide imaging in vivo not only provides more insight into NGR’s targeting process, including bio-distribution and pharmacokinetics, but also reveals angiogenic activities related to tumor progression and malignancy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

722.72

Formula

C22H37F3N10O10S2

Sequence

Cys-Asn-Gly-Arg-Cys-Gly

Sequence Shortening

CNGRCG

中文名称

NGR肽三氟乙酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 50 mg/mL (69.18 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3837 mL 6.9183 mL 13.8366 mL
5 mM 0.2767 mL 1.3837 mL 2.7673 mL
10 mM 0.1384 mL 0.6918 mL 1.3837 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Enyedi KN, et al. NGR-peptide-drug conjugates with dual targeting properties. NGR-peptide-drug conjugates with dual targeting properties.

    [2]. Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46.

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