Tat-NR2Baa; 纯度: 96.26%
Tat-NR2BAA 是 Tat-NR2B9c (HY-P0117) 的对照肽 (control peptide)，没有活性。Tat-NR2BAA 的序列与 Tat-NR2B9c 相似，但在 COOH 末端 tSXV 基序中有一个双点突变，这使得它无法结合 PSD-95。Tat-NR2B9c 是一种可通透细胞膜的多肽，破坏 PSD-95/NMDAR 的结合。
Tat-NR2Baa Chemical Structure
CAS No. : 847829-41-8
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 1 mg | ￥2200 | In-stock | |
| 5 mg | ￥5500 | In-stock | |
| 10 mg | ￥9500 | In-stock | |
| 50 mg | ; | 询价 | ; |
| 100 mg | ; | 询价 | ; |
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Tat-NR2Baa 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
| 生物活性 |
Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95[1][2]. |
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| 体外研究 (In Vitro) |
Tat-NR2BAA (125 ng; 20 mins) does not effects interactions between PSD-95 and NR2B subunits. In contrast, coimmunoprecipitation of PSD-95 with NR2B subunits is markedly decreased in rats pretreated with the disrupting peptide Tat-NR2B9c in lumbar dorsal horn tissue[1]. Tat-NR2Baa (125 ng or 1.25 μg; 20 minutes before collection of lumbar dorsal horn tissue) is the control group of Tat-NR2B9c. Tat-NR2B9c produces a significant and robust reduction of postdischarge, indicating the hyperexcitability of the cell. But Tat-NR2Baa has no effects, even at a dose 100× greater than the active peptide Tat-NR2B9c (HY-P0117)[1].Tat-NR2Baa (1 μM; pre-treatment 1 hour) is the control group in the Co-IP assay. Tat-NR2B9c (1 μM) disrupts NR2B/PSD95 interaction, and the coupling of NR2B to PSD-95 is more sensitive than NR2A/PSD95 to disruption in hippocampal neurons[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
2474.83 |
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| Formula |
C103H184N42O29 |
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| CAS 号 |
847829-41-8 |
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| Sequence |
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ala-Asp-Ala |
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| Sequence Shortening |
YGRKKRRQRRRKLSSIEADA |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 参考文献 |
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