Anemarsaponin B(Synonyms: 知母皂苷 B)

天然产物 糖类和糖苷 Saccharides and Glycosides

Anemarsaponin B;(Synonyms: 知母皂苷 B)

Anemarsaponin B 是一种甾体皂苷。Anemarsaponin B 降低 iNOSCOX-2 的蛋白和 mRNA 水平。Anemarsaponin B 减少促炎细胞因子的表达和产生,包括 TNF-α 和 IL-6。Anemarsaponin B 通过阻断 IκBα 的磷酸化来抑制 NF-κB 的 p65 亚基的核转位。Anemarsaponin B 还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 (MLK3) 的磷酸化。 具有抗炎作用。

Anemarsaponin B(Synonyms: 知母皂苷 B)

Anemarsaponin B Chemical Structure

CAS No. : 139051-27-7

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5 mg ¥2690 询问价格 货期
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生物活性

Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect [1].

IC50 Target[1]

COX-2

;

p65

;

iNOS

;

分子量

903.06

Formula

C45H74O18

CAS 号

139051-27-7

中文名称

知母皂苷 B

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kim JY, et al. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem Toxicol. 2009 Jul;47(7):1610-7.