Actein(Synonyms: 黄肉楠碱)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Actein;(Synonyms: 黄肉楠碱) 纯度: 98.58%

Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。

Actein(Synonyms: 黄肉楠碱)

Actein Chemical Structure

CAS No. : 18642-44-9

规格 价格 是否有货 数量
5 mg ￥7400 In-stock
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生物活性

Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo[1][2].

分子量

676.83

Formula

C37H56O11
CAS 号

18642-44-9
中文名称

黄肉楠碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
参考文献

  • [1]. Yang ZC, et al. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183.

    [2]. Ji L, et al. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. 2017 Nov 1;8(68):112498-112515.