CTAP TFA

发表于由

CTAP TFA; 纯度: 99.48%

CTAP TFA 是一种强效、高选择性的脑渗透类阿片受体 (μ opioid receptor）拮抗剂 (IC50=3.5 nM)，对 δ opioid 受体 (IC50=4500 nM) 和生长抑素受体具有超过1200倍的选择性。CTAP TFA 可用于L -多巴胺 (HY-N0304) 诱导的运动障碍 (LID) 的研究。

CTAP TFA 

CTAP TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥2200 In-stock
5 mg ￥5500 In-stock
10 mg ￥9300 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

CTAP TFA 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

CTAP TFA is a potent, highly selective, and brain penetrant μ opioid receptor antagonist (IC50=3.5 nM) and displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID)[1].

IC50 & Target

IC50: 3.5 nM (μ opioid receptor)
IC50: 4500 nM (δ opioid receptor)[1]
分子量

1218.32

Formula

C53H70F3N13O12S2
Sequence

Phe-Cys-Tyr-Trp-Arg-Thr-Pen-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
Sequence Shortening

FCYWRT{Pen}T-NH2 (Disulfide bridge:Cys2-Pen7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light, stored under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (82.08 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8208 mL 4.1040 mL 8.2080 mL
5 mM 0.1642 mL 0.8208 mL 1.6416 mL
10 mM 0.0821 mL 0.4104 mL 0.8208 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Mitchell J Bartlett, et al. Highly-selective µ-opioid Receptor Antagonism Does Not Block L-DOPA-induced Dyskinesia in a Rodent Model.BMC Res Notes