Peptide5

Peptide5;

Peptide5 是 connexin 43 的模拟肽,减少动物脊髓损伤后肿胀、星形胶质细胞增生和神经元细胞死亡。

Peptide5amp;;

Peptide5 Chemical Structure

CAS No. : 916977-43-0

规格 是否有货
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生物活性

Peptide5, a connexin 43 mimetic peptide, reduce animals swelling, astrogliosis, and neuronal cell death after spinal cord injury[1]

体外研究
(In Vitro)

Peptide5, significantly reduces the degree of spinal cord injury (SCI) in a rodent ex vivo model. Peptide5 produces the more significant reduction in swelling and is analyzed further. Treatment with peptide5 reduced both the level of Cx43 and the number of glial fibrillary acidic protein (GFAP)-positive astrocytes, and at the same time reduces the loss of NeuN- and SMI-32–positive neurons in a concentration- and time-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Peptide5 is could be used to treat traumatic spinal cord injured rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1395.58

Formula

C60H98N16O20S

CAS 号

916977-43-0

Sequence Shortening

VDCFLSRPTEKT

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Simon J O’Carroll, et al. Connexin 43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury. Cell Commun Adhes. 2008 May;15(1):27-42.

    [2]. Yilin Mao, et al. Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats. Exp Brain Res. 2017 Oct;235(10):3033-3048.