Adrenomedullin (AM) (22-52), human TFA(Synonyms: 22-52-Adrenomedullin (human) (TFA))

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Adrenomedullin (AM) (22-52), human TFA;(Synonyms: 22-52-Adrenomedullin (human) (TFA))

Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) (TFA)，NH2 末端截短的 adrenomedullin 类似物，为肾上腺髓质素 (adrenomedullin receptor) 受体拮抗剂，同时在猫后肢血管床中，对降钙素基因相关肽 (CGRP) 受体也具有拮抗作用。

Adrenomedullin (AM) (22-52), human TFAamp;;(Synonyms: 22-52-Adrenomedullin (human) (TFA))

Adrenomedullin (AM) (22-52), human TFA Chemical Structure

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Adrenomedullin (AM) (22-52), human TFA 的其他形式现货产品:

Adrenomedullin (AM) (22-52), human

生物活性

Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist. Adrenomedullin (AM) (22-52), human also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat[1].

IC50 Target

Adrenomedullin receptor, CGRP receptor[1]
体外研究
(In Vitro)

Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist[1].
Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3690.06

Formula

C161H253N46F3O50
Sequence

Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2
Sequence Shortening

TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Champion HC, et al. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997 Jan;272(1 Pt 2):R234-42.

    [2]. Ziolkowska A, et al. Effects of adrenomedullin and its fragment 22-52 on basal and ACTH-stimulated secretion of cultured rat adrenocortical cells. Int J Mol Med. 2003 May;11(5):613-5.