RA375;
RA375 是 RPN13 (26S 蛋白酶体亚基) 抑制剂。RA375 激活 UPR 信号、ROS 产生和凋亡。RA375 的抗肿瘤活性是 RA190的 10 倍。
RA375 Chemical Structure
规格 | 价格 | 是否有货 | |
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5 mg | ¥3500 | 询问价格 货期 | |
10 mg | ¥6000 | 询问价格 货期 | |
50 mg | ¥17000 | 询问价格 货期 | |
100 mg | ¥26000 | 询问价格 货期 |
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生物活性 |
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1]. |
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体内研究 (In Vivo) |
RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
589.00 |
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Formula |
C30H25ClN4O7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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溶解性数据 |
In Vitro:;
DMSO : 125 mg/mL (212.22 mM; Need ultrasonic) 配制储备液
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参考文献 |
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