Davunetide; 纯度: 98.85%
Davunetide 是一种八个氨基酸多肽,来源于活性依赖性神经保护蛋白 (ADNP),一种存在于哺乳动物中枢神经系统中的神经营养因子。Davunetide 具有神经保护、神经营养和认知保护特性。Davunetide 是一种微管稳定肽 (microtubule-stabilizing),在体外与神经元特异性βIII微管蛋白相互作用并稳定其活性。Davunetide 可透过血脑屏障,无毒。Davunetide 抑制Aβ聚集和Aβ诱导的神经毒性。
Davunetide Chemical Structure
CAS No. : 211439-12-2
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥500 | In-stock | |
5 mg | ¥1000 | In-stock | |
10 mg | ¥1700 | In-stock | |
25 mg | ¥3400 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Davunetide 相关产品
bull;相关化合物库:
- Drug Repurposing Compound Library Plus
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Neuronal Signaling Compound Library
- Clinical Compound Library
- Anti-Aging Compound Library
- Drug Repurposing Compound Library
- Diabetes Related Compound Library
- Cytoskeleton Compound Library
- Anti-Alzheimer’s Disease Compound Library
- Neuroprotective Compound Library
- Anti-Lung Cancer Compound Library
- Neurodegenerative Disease-related Compound Library
- Rare Diseases Drug Library
- Peptide Library
生物活性 |
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3]. |
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体内研究 (In Vivo) |
Davunetide (2 μg/kg; Intranasally; daily, 5 days a week, for 16 weeks) shows protective effects for central nervous system complications in a diabetes rat model[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
824.92 |
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Formula |
C36H60N10O12 |
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CAS 号 |
211439-12-2 |
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Sequence Shortening |
NAPVSIPQ |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:;
H2O : ≥ 250 mg/mL (303.06 mM) DMSO : 125 mg/mL (151.53 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。
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参考文献 |
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