NEP(1-40)

发表于由

NEP(1-40);

NEP(1-40) 是 Nogo-66 受体 (NgR) 的肽类拮抗剂，通过限制髓蛋白抑制逆转损伤引起的小胶质细胞形态分布的改变。

NEP(1-40)amp;;

NEP(1-40) Chemical Structure

CAS No. : 475221-20-6

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生物活性

NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1].

体内研究
(In Vivo)

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 74 male Sprague-Dawley rats (328-377 g)[1].
Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration: IP, 15 min and 19 h post-injury.
Result: Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury

分子量

4625.11

Formula

C206H324N56O65
CAS 号

475221-20-6
Sequence

Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2
Sequence Shortening

RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jenna M Ziebell, et al. Nogo Presence Is Inversely Associated With Shifts in Cortical Microglial Morphology Following Experimental Diffuse Brain Injury. Neuroscience. 2017 Sep 17;359:209-223.